Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses (Q45248566)

11 December 2017

Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses (English)

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11 December 2017

Robert Oliver

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11 December 2017

Ellen Friday

2

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11 December 2017

Francesco Turturro

3

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11 December 2017

Ashley Lacy

4

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11 December 2017

Tomas Welbourne

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11 December 2017

1 February 2005

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American Journal of Physiology - Renal Physiology

11 December 2017

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11 December 2017

288

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11 December 2017

6

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11 December 2017

F1257-66

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

11 December 2017

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Trade-offs in the adaptation to acidosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Effects of extracellular pH on intracellular pH-regulation and growth in a human colon carcinoma cell-line

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

PPARgamma ligand attenuates PDGF-induced mesangial cell proliferation: role of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive ox

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Acidic environment causes apoptosis by increasing caspase activity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Citrate excretion: a window on renal metabolism

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Role of c-SRC and ERK in acid-induced activation of NHE3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone acts by PPARγ and PPARγ-independent pathways on LLC-PK1-F+acid-base metabolism

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00205.2004

10.1152/AJPRENAL.00205.2004

21 January 2018

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11 December 2017

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