RUNX family transcription factor 1 (Q4392325)

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mammalian protein found in Homo sapiens
  • RUNX1/ZNF687 fusion
  • PEBP2-alpha B
  • runt-related transcription factor 1
  • PEA2-alpha B
  • RUNX1
  • SL3-3 enhancer factor 1 alpha B subunit
  • oncogene AML-1
  • AML1-EVI-1 fusion protein
  • core-binding factor, runt domain, alpha subunit 2
  • runt related transcription factor 1
  • polyomavirus enhancer-binding protein 2 alpha B subunit
  • SL3/AKV core-binding factor alpha B subunit
  • Core-binding factor subunit alpha-2
  • CBF-alpha-2
  • acute myeloid leukemia 1 protein
  • Core Binding Factor Alpha 2 Subunit
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Language Label Description Also known as
English
RUNX family transcription factor 1
mammalian protein found in Homo sapiens
  • RUNX1/ZNF687 fusion
  • PEBP2-alpha B
  • runt-related transcription factor 1
  • PEA2-alpha B
  • RUNX1
  • SL3-3 enhancer factor 1 alpha B subunit
  • oncogene AML-1
  • AML1-EVI-1 fusion protein
  • core-binding factor, runt domain, alpha subunit 2
  • runt related transcription factor 1
  • polyomavirus enhancer-binding protein 2 alpha B subunit
  • SL3/AKV core-binding factor alpha B subunit
  • Core-binding factor subunit alpha-2
  • CBF-alpha-2
  • acute myeloid leukemia 1 protein
  • Core Binding Factor Alpha 2 Subunit

Statements

molecular function
DNA binding
determination method
IDA
IEA
5 references
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196
determination method
IEA
retrieved
21 June 2018
stated in
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196
determination method
IDA
retrieved
21 June 2018
stated in
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196
determination method
IDA
retrieved
21 June 2018
stated in
The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196
determination method
IDA
protein binding
determination method
IPI
16 references
retrieved
8 April 2019
stated in
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
retrieved
8 April 2019
stated in
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IPI
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IMP
6 references
retrieved
8 April 2019
stated in
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IMP
retrieved
8 April 2019
stated in
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IMP
retrieved
8 April 2019
stated in
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IDA
retrieved
8 April 2019
stated in
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IDA
retrieved
8 April 2019
stated in
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
GOA
curator
UniProt
UniProt protein ID
Q01196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IDA
retrieved
8 April 2019
stated in
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196
determination method
IDA
Gene Atlas image
PBB GE RUNX1 208129 x at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D050676
subject named as
Core Binding Factor Alpha 2 Subunit
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q4392325&oldid=2022905280"