Lamin A/C (Q4253573)

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mammalian protein found in Homo sapiens
  • IDC
  • epididymis secretory sperm binding protein
  • FPLD2
  • EMD2
  • FPLD
  • LDP1
  • LGMD1B
  • PRO1
  • 70 kDa lamin
  • LMNC
  • FPL
  • lamin A/C-like 1
  • lamin
  • CMD1A
  • CMT2B1
  • LMNA
  • LFP
  • mandibuloacral dysplasia type A
  • prelamin-A/C
  • HGPS
  • LMNL1
  • CDCD1
  • CDDC
  • LMN1
  • renal carcinoma antigen NY-REN-32
  • A-type lamin
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Language Label Description Also known as
English
Lamin A/C
mammalian protein found in Homo sapiens
  • IDC
  • epididymis secretory sperm binding protein
  • FPLD2
  • EMD2
  • FPLD
  • LDP1
  • LGMD1B
  • PRO1
  • 70 kDa lamin
  • LMNC
  • FPL
  • lamin A/C-like 1
  • lamin
  • CMD1A
  • CMT2B1
  • LMNA
  • LFP
  • mandibuloacral dysplasia type A
  • prelamin-A/C
  • HGPS
  • LMNL1
  • CDCD1
  • CDDC
  • LMN1
  • renal carcinoma antigen NY-REN-32
  • A-type lamin

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Emerin-prelamin A interplay in human fibroblasts
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Myotonic dystrophy protein kinase is critical for nuclear envelope integrity
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
LINC complex alterations in DMD and EDMD/CMT fibroblasts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
retrieved
8 April 2019
stated in
Prenylated prelamin A interacts with Narf, a novel nuclear protein
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IPI
cell component
nuclear envelope
determination method
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
TAS
retrieved
8 April 2019
stated in
Samp1 is functionally associated with the LINC complex and A-type lamina networks
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IEA
retrieved
8 April 2019
stated in
Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies
GOA
curator
UniProt
UniProt protein ID
P02545
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IDA
retrieved
8 April 2019
stated in
The effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02545
determination method
IDA
biological process
Gene Atlas image
PBB GE LMNA 203411 s at fs.png
732 × 530; 12 KB
0 references
Commons category
Lamin A or C
0 references

Identifiers

MeSH descriptor ID
D034904
subject named as
Lamin Type A
0 references
Freebase ID
/m/02pwm8b
0 references
 
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