Cathepsin A (Q423561)

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mammalian protein found in Homo sapiens

urinary kininase
beta-galactosidase 2
lysosomal carboxypeptidase A
protective protein cathepsin A
carboxypeptidase C
beta-galactosidase protective protein
PPCA
Carboxypeptidase L
Protective protein for beta-galactosidase
CTSA
carboxypeptidase-L
carboxypeptidase Y-like kininase
deamidase
lysosomal protective protein

Language	Label	Description	Also known as
English	Cathepsin A	mammalian protein found in Homo sapiens	urinary kininase beta-galactosidase 2 lysosomal carboxypeptidase A protective protein cathepsin A carboxypeptidase C beta-galactosidase protective protein PPCA Carboxypeptidase L Protective protein for beta-galactosidase CTSA carboxypeptidase-L carboxypeptidase Y-like kininase deamidase lysosomal protective protein

Statements

1 reference

13 November 2019

UniProt protein ID

Peptidase S10, serine carboxypeptidase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10619

Alpha/Beta hydrolase fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10619

Serine carboxypeptidase, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine carboxypeptidases, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

enzyme activator activity

determination method

1 reference

8 April 2019

Galactosialidosis: a direct evidence that a 46-kilodalton protein restores deficient enzyme activities in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

exo-alpha-sialidase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10619&geneProductId=UniProtKB:P10619

determination method

serine-type carboxypeptidase activity

determination method

3 references

8 April 2019

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10619&geneProductId=UniProtKB:P10619

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

lysosomal lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

lumenal side of lysosomal membrane

determination method

1 reference

8 April 2019

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

extracellular exosome

determination method

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10619&geneProductId=UniProtKB:P10619

determination method

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10619&geneProductId=UniProtKB:P10619

determination method

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10619&geneProductId=UniProtKB:P10619

determination method

extracellular region

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

azurophil granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

biological process

regulation of protein stability

determination method

1 reference

8 April 2019

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

glycosphingolipid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

8 April 2019

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

regulation of chaperone-mediated autophagy

determination method

1 reference

8 April 2019

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

proteolysis involved in cellular protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

positive regulation of catalytic activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

negative regulation of chaperone-mediated autophagy

determination method

1 reference

8 April 2019

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10619

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Family with sequence similarity 209 member A

determination method

two-hybrid screening

0 references

Gene Atlas image

PBB GE CTSA 200661 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P10619

1 reference

Identifiers.org

Serine carboxypeptidases, histidine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10619

Serine carboxypeptidase, serine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10619

Identifiers

MeSH descriptor ID

subject named as

Cathepsin A

0 references

D08.811.277.656.224.062

0 references

D08.811.277.656.350.245.260

0 references

D08.811.277.656.959.200

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

0 references

Ensembl protein ID

ENSP00000191018

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000191018

ENSP00000361537

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361537

ENSP00000346952

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346952

ENSP00000361562

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361562

ENSP00000408533

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408533

ENSP00000475524

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475524

ENSP00000475827

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475827

ENSP00000476235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476235

ENSP00000493613

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493613

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(6 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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