integrin subunit alpha 2 (Q4201948)

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mammalian protein found in Homo sapiens
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
  • VLA-2 subunit alpha
  • GPIa
  • platelet antigen Br
  • human platelet alloantigen system 5
  • collagen receptor
  • platelet membrane glycoprotein Ia
  • very late activation protein 2 receptor, alpha-2 subunit
  • CD49 antigen-like family member B
  • integrin alpha-2
  • platelet glycoprotein GPIa
  • ITGA2
  • alpha 2 subunit of VLA-2 receptor
  • Integrin alpha2
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Language Label Description Also known as
English
integrin subunit alpha 2
mammalian protein found in Homo sapiens
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
  • VLA-2 subunit alpha
  • GPIa
  • platelet antigen Br
  • human platelet alloantigen system 5
  • collagen receptor
  • platelet membrane glycoprotein Ia
  • very late activation protein 2 receptor, alpha-2 subunit
  • CD49 antigen-like family member B
  • integrin alpha-2
  • platelet glycoprotein GPIa
  • ITGA2
  • alpha 2 subunit of VLA-2 receptor
  • Integrin alpha2

Statements

molecular function
protein binding
determination method
IPI
9 references
retrieved
8 April 2019
stated in
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Evidence for the location of a binding sequence for the alpha 2 beta 1 integrin of endothelial cells, in the beta 1 subunit of laminin
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
SHARPIN is an endogenous inhibitor of β1-integrin activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
retrieved
8 April 2019
stated in
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IPI
cell component
cell surface
determination method
IDA
IEA
7 references
retrieved
3 January 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IEA
retrieved
3 January 2017
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
retrieved
3 January 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
retrieved
3 January 2017
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
retrieved
3 January 2017
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
retrieved
3 January 2017
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
retrieved
3 January 2017
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301
determination method
IDA
cell surface
determination method
HDA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IEA
retrieved
8 April 2019
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IDA
retrieved
8 April 2019
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IDA
retrieved
8 April 2019
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
IDA
retrieved
8 April 2019
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
HDA
retrieved
8 April 2019
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
HDA
retrieved
8 April 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P17301
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301
determination method
HDA
biological process

Identifiers

MeSH descriptor ID
D039421
subject named as
Integrin alpha2
0 references
Freebase ID
/m/02q6htb
0 references
 
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