proopiomelanocortin (Q418896)

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mammalian protein found in Homo sapiens

corticotropin-lipotropin precursor
POMC(1-241)
proopiomelanocortin preproprotein
corticotropin-like intermediary peptide
POMC
opiomelanocortin prepropeptide
pro-opiomelanocortin

Language	Label	Description	Also known as
English	proopiomelanocortin	mammalian protein found in Homo sapiens	corticotropin-lipotropin precursor POMC(1-241) proopiomelanocortin preproprotein corticotropin-like intermediary peptide POMC opiomelanocortin prepropeptide pro-opiomelanocortin

Statements

protein precursor

1 reference

10 April 2019

UniProt protein ID

1 reference

18 December 2019

UniProt protein ID

pro-opiomelanocortin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01189

Corticotropin cleavage from POMC

0 references

Opiodes neuropeptide family

1 reference

based on heuristic

inferred from protein domain or family

Pro-opiomelanocortin/corticotropin, ACTH, central region, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pro-opiomelanocortin N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

18 December 2019

UniProt protein ID

1 reference

18 December 2019

UniProt protein ID

molecular function

type 3 melanocortin receptor binding

determination method

1 reference

8 April 2019

Novel binding motif of ACTH analogues at the melanocortin receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

hormone activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

G protein-coupled receptor binding

determination method

1 reference

24 April 2018

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

type 4 melanocortin receptor binding

determination method

1 reference

8 April 2019

Novel binding motif of ACTH analogues at the melanocortin receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

neuropeptide hormone activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

G protein-coupled receptor binding

determination method

determination method

1 reference

24 April 2018

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

peroxisomal matrix

determination method

1 reference

24 April 2018

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

secretory granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

extracellular space

determination method

1 reference

24 April 2018

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

secretory granule

determination method

3 references

extracellular space

determination method

extracellular space

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

biological process

glucose homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

cellular pigmentation

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

generation of precursor metabolites and energy

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

regulation of glycogen metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

alpha-MSH and its receptors in regulation of tumor necrosis factor-alpha production by human monocyte/macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

regulation of appetite

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

signal transduction

determination method

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

positive regulation of neutrophil mediated killing of fungus

determination method

1 reference

24 April 2018

Antimicrobial effects of alpha-MSH peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

neuropeptide signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

determination method

Gene Atlas image

PBB GE POMC 205720 at fs.png
732 × 530; 8 KB

0 references

Pro-opiomelanocortin/corticotropin, ACTH, central region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01189

Pro-opiomelanocortin N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01189

Opiodes neuropeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01189

0 references

beta-lipotropin

0 references

N-Terminal peptide of proopiomelanocortin

0 references

Identifiers

CAS Registry Number

1 reference

https://chem.nlm.nih.gov/chemidplus/rn/66796-54-1

RefSeq protein ID

1 reference

27 December 2019

1 reference

27 December 2019

1 reference

27 December 2019

1 reference

27 December 2019

0 references

UniProt protein ID

1 reference

18 December 2019

UniProt protein ID

1 reference

6 April 2020

Encyclopædia Britannica Online ID

science/proopiomelanocortin

subject named as

proopiomelanocortin

0 references

Ensembl protein ID

ENSP00000384092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384092

ENSP00000264708

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264708

ENSP00000370171

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370171

ENSP00000379170

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379170

ENSP00000387993

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387993

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Wolfram Language entity code

Entity["Protein", "POMC"]

0 references

Sitelinks

Wikipedia(19 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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