Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. (Q41700895)

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4 January 2020

title

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC (English)

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4 January 2020

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GOA release 2020-03-11

Par-6 Dmel_CG5884

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GOA release 2020-03-11

author

Scott Atwood

1

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4 January 2020

author name string

Chiswili Chabu

2

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4 January 2020

Rhiannon R Penkert

3

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4 January 2020

Chris Q Doe

4

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4 January 2020

Kenneth E Prehoda

5

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4 January 2020

language of work or name

English

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publication date

28 August 2007

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4 January 2020

published in

Journal of Cell Science

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4 January 2020

volume

120

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4 January 2020

issue

Pt 18

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4 January 2020

page(s)

3200-3206

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describes a project that uses

4 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

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Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

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Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans

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Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition

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Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport

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Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

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Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

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Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry

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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

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PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

6 June 2018

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DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

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Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

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Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos

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CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17726059

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/JCS.014902

1 reference

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4 January 2020

1 reference

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4 January 2020

1 reference