Amyloid beta-protein and the genetics of Alzheimer's disease (Q41074945)

26 September 2017

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title

Amyloid beta-protein and the genetics of Alzheimer's disease (English)

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26 September 2017

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Selkoe DJ

1

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PubMed ID

8756120

26 September 2017

language of work or name

English

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publication date

1 August 1996

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Journal of Biological Chemistry

26 September 2017

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26 September 2017

271

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26 September 2017

31

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26 September 2017

18295-18298

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

26 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Disruption of the cytoskeleton in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Diagnostic significance of skin immunolabelling with antibody against native cerebral amyloid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

beta-Amyloid protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease. An autopsy-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Complement activation by beta-amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Serum amyloid p and related molecules associated with the acute-phase response in alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.31.18295

21 January 2018

Identifiers

DOI

10.1074/JBC.271.31.18295

1 reference

26 September 2017

1 reference

PubMed ID

8756120