Phospholamban (Q410105)

http://www.ebi.ac.uk/interpro/protein/P26678

Phospholamban (Ca2+-channel and Ca2+-ATPase Regulator)

1 reference

Transporter Classification Database ID

1.A.50.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

1 reference

13 November 2019

enzyme inhibitor activity

1 reference

9 May 2019

Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

1 reference

9 May 2019

Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

calcium channel regulator activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

3 references

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

ATPase inhibitor activity

IPI

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

identical protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

mitochondrial membranes

1 reference

9 May 2019

sarcoplasmic reticulum membrane

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

perinuclear region of cytoplasm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

calcium ion-transporting ATPase complex

1 reference

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

protein-containing complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

biological process

Notch signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of ryanodine-sensitive calcium-release channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of calcium ion binding

regulation of cardiac conduction

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26678&geneProductId=UniProtKB:P26678

negative regulation of catalytic activity

TAS

1 reference

9 May 2019

Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

cardiac muscle tissue development

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of heart contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

response to testosterone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of ATPase-coupled calcium transmembrane transporter activity

1 reference

9 May 2019

Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of calcium ion import

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

cellular calcium ion homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of relaxation of cardiac muscle

1 reference

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of calcium ion transmembrane transporter activity

IC

1 reference

9 May 2019

Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of heart rate

NAS

1 reference

9 May 2019

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of calcium ion import

IMP

1 reference

9 May 2019

Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of ATPase-coupled calcium transmembrane transporter activity

1 reference

8 April 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of calcium ion transport

1 reference

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of cardiac muscle cell membrane potential

1 reference

9 May 2019

Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of the force of heart contraction by cardiac conduction

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of relaxation of muscle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

negative regulation of calcium ion import into sarcoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

protein homooligomerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678

relaxation of cardiac muscle

1 reference

9 May 2019

Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26678