Sex determining region Y (Q409114)

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mammalian protein found in Homo sapiens

truncated sex-determining region Y protein
SRY
testis-determining factor on Y
essential protein for sex determination in human males
sex-determining region on Y
sex-determining region Y protein
Testis-determining factor

Language	Label	Description	Also known as
English	Sex determining region Y	mammalian protein found in Homo sapiens	truncated sex-determining region Y protein SRY testis-determining factor on Y essential protein for sex determination in human males sex-determining region on Y sex-determining region Y protein Testis-determining factor

Statements

1 reference

13 November 2019

UniProt protein ID

High mobility group box domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05066

Transcription factor SRY

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05066

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SRY .png
2,100 × 2,100; 3.41 MB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

transcription factor binding

determination method

1 reference

8 April 2019

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

calmodulin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

10 September 2018

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

SRY, like HMG1, recognizes sharp angles in DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

5 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

protein binding

determination method

3 references

5 June 2018

Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

5 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

determination method

6 references

5 June 2018

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

SRY, like HMG1, recognizes sharp angles in DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

5 June 2018

A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

determination method

7 references

8 April 2019

SRY, like HMG1, recognizes sharp angles in DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

biological process

cell differentiation

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

regulation of transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

sex differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

positive regulation of male gonad development

determination method

1 reference

8 April 2019

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05066&geneProductId=UniProtKB:Q05066

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

male sex determination

determination method

3 references

8 April 2019

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

central nervous system development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

neuron differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05066

determination method

http://purl.uniprot.org/uniprot/Q05066

1 reference

Identifiers.org

High mobility group box domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05066

Commons category

SRY

0 references

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000372547

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000372547

1 reference

Freebase Data Dumps

publication date

28 October 2013

divers/gène_SRY/185888

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(31 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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