Werner and Bloom helicases are involved in DNA repair in a complementary fashion (Q40751512)

23 September 2017

Werner and Bloom helicases are involved in DNA repair in a complementary fashion (English)

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23 September 2017

Shunichi Takeda

4

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author name string

Osamu Imamura

1

1 reference

23 September 2017

Kumiko Fujita

2

1 reference

23 September 2017

Chie Itoh

3

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23 September 2017

Yasuhiro Furuichi

5

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23 September 2017

Takehisa Matsumoto

6

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23 September 2017

language of work or name

English

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publication date

1 January 2002

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23 September 2017

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23 September 2017

21

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23 September 2017

6

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23 September 2017

954-963

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205143

23 September 2017

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cites work

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Effects of topoisomerase II inhibition in lymphoblasts from patients with progeroid and "chromosome instability" syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The gene responsible for Werner syndrome may be a cell division "counting" gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The chicken HPRT gene: a counter selectable marker for the DT40 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Mutator phenotype of Werner syndrome is characterized by extensive deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Guanyl-C8-arylamination of DNA by the ultimate carcinogen of 4-nitroquinoline-1-oxide: a spectrophotometric titration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The Werner syndrome protein is a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The Bloom's syndrome gene product is a 3'-5' DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The Bloom's syndrome gene product promotes branch migration of holliday junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Malignant transformation of Bloom syndrome B-lymphoblastoid cell lines by carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Cytotoxicity of monofunctional alkylating agents. Methyl methanesulfonate and methyl-N'-nitro-N-nitrosoguanidine have different mechanisms of toxicity for 10T1/2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Homologous DNA recombination in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

UV damage and repair mechanisms in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Possible association of BLM in decreasing DNA double strand breaks during DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Repair of pyrimidine dimer ultraviolet light photoproducts by human cell extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Positional cloning of the Werner's syndrome gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Light chain gene conversion continues at high rate in an ALV-induced cell line.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Spontaneous and induced chromosomal instability in Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Studies on the ultraviolet light sensitivity of Bloom's syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Sister-chromatid exchanges induced by ultraviolet light in Bloom's syndrome fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Growth characteristics of Werner syndrome cells in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205143

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205143

1 reference

Dimensions Publication ID

23 September 2017

1041208970

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Fatcat ID

release_p7qf27givfeihh3ygosahkwcp4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/p7qf27givfeihh3ygosahkwcp4

24 November 2022

mapped directly with Wikidata item

1 reference