Interleukin 1 receptor antagonist (Q4066948)

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mammalian protein found in Homo sapiens

• IL1 inhibitor
• intracellular interleukin-1 receptor antagonist (icIL-1ra)
• ICIL-1RA
• interleukin-1 receptor antagonist protein
• IL1RN
• intracellular IL-1 receptor antagonist type II
• type II interleukin-1 receptor antagonist

edit

Language	Label	Description	Also known as
English	Interleukin 1 receptor antagonist	mammalian protein found in Homo sapiens	IL1 inhibitor intracellular interleukin-1 receptor antagonist (icIL-1ra) ICIL-1RA interleukin-1 receptor antagonist protein IL1RN intracellular IL-1 receptor antagonist type II type II interleukin-1 receptor antagonist

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P18510

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P18510

encoded by

IL1RN

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P18510

molecular function

interleukin-1 type I receptor antagonist activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

interleukin-1, type II receptor binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IPI

protein binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IPI

interleukin-1, type I receptor binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IPI

interleukin-1 type II receptor antagonist activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

interleukin-1 receptor binding

determination method

IDA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

17 October 2017

stated in

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

cytokine activity

determination method

IBA

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

interleukin-1 receptor antagonist activity

determination method

IDA

TAS

3 references

retrieved

17 October 2017

stated in

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

TAS

retrieved

17 October 2017

stated in

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

interleukin-1 receptor binding

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

interleukin-1 receptor antagonist activity

determination method

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

8 April 2019

stated in

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

cytokine activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

vesicle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

plasma membrane

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

TAS

intracellular anatomical structure

determination method

NAS

1 reference

retrieved

1 January 2018

stated in

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

NAS

extracellular region

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

extracellular exosome

determination method

IDA

2 references

retrieved

17 October 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

extracellular space

determination method

IDA

IEA

5 references

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

17 October 2017

stated in

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

extracellular space

determination method

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

8 April 2019

stated in

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

8 April 2019

stated in

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

extracellular exosome

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

HDA

biological process

negative regulation of interleukin-1-mediated signaling pathway

determination method

IDA

2 references

retrieved

17 October 2017

stated in

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

17 October 2017

stated in

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

lipid metabolism

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

response to glucocorticoid

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

insulin secretion

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

acute-phase response

determination method

IDA

1 reference

retrieved

17 October 2017

stated in

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IDA

negative regulation of heterotypic cell-cell adhesion

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

negative regulation of cytokine-mediated signaling pathway

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IEA

inflammatory response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

immune response

determination method

IEA

NAS

2 references

retrieved

8 April 2019

stated in

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist

GOA

curator

UniProt

UniProt protein ID

P18510

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

fever generation

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18510&geneProductId=UniProtKB:P18510

determination method

IBA

regulation of signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

cytokine-mediated signaling pathway

determination method

IBA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

neutrophil chemotaxis

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

positive regulation of interleukin-6 production

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

positive regulation of JNK cascade

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

interleukin-1-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

TAS

cellular response to lipopolysaccharide

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IBA

negative regulation of interleukin-1-mediated signaling pathway

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IEA

retrieved

8 April 2019

stated in

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

retrieved

8 April 2019

stated in

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18510

determination method

IDA

Gene Atlas image

PBB GE IL1RN 212657 s at fs.png
732 × 530; 10 KB

0 references

exact match

https://identifiers.org/uniprot:P18510

1 reference

stated in

Identifiers.org

UniProt protein ID

P18510

reference URL

https://registry.identifiers.org/registry/uniprot

http://purl.uniprot.org/uniprot/P18510

1 reference

stated in

Identifiers.org

UniProt protein ID

P18510

reference URL

https://registry.identifiers.org/registry/uniprot

https://www.ncbi.nlm.nih.gov/protein/P18510

1 reference

stated in

Identifiers.org

UniProt protein ID

P18510

reference URL

https://registry.identifiers.org/registry/uniprot

Identifiers

MeSH descriptor ID

D053590

subject named as

Interleukin 1 Receptor Antagonist Protein

0 references

MeSH tree code

D12.644.276.374.460

0 references

D23.529.374.460

0 references

D12.776.467.374.460

0 references

RefSeq protein ID

NP_000568

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

NP_001305843

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

NP_776213

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

NP_776214

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

NP_776215

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

XP_011509423

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3557

NP_001366289

1 reference

stated in

NCBI Gene

retrieved

4 April 2020

Entrez Gene ID

3557

UniProt protein ID

P18510

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P18510

Ensembl protein ID

ENSP00000259206

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000259206

ENSP00000329072

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000329072

ENSP00000387173

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000387173

ENSP00000354816

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000354816

ENSP00000387210

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000387210

Freebase ID

/m/02r96vk

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1ILR

1 reference

stated in

UniProt

UniProt protein ID

P18510

retrieved

5 August 2016

language of work or name

English

1ILT

1 reference

stated in

UniProt

UniProt protein ID

P18510

retrieved

5 August 2016

language of work or name

English

1IRA

1 reference

stated in

UniProt

UniProt protein ID

P18510

retrieved

5 August 2016

language of work or name

English

1IRP

1 reference

stated in

UniProt

UniProt protein ID

P18510

retrieved

5 August 2016

language of work or name

English

2IRT

1 reference

stated in

UniProt

UniProt protein ID

P18510

retrieved

5 August 2016

language of work or name

English

 

Sitelinks

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