Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy"). (Q40483217)

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23 October 2019

review article

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MDMA

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title

Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") (English)

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23 October 2019

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23 October 2019

author name string

A R Green

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1

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23 October 2019

G M Goodwin

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3

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23 October 2019

publication date

1 June 1995

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23 October 2019

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23 October 2019

volume

119

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23 October 2019

page(s)

247-260

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23 October 2019

issue

3

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https://scigraph.springernature.com/pub.10.1007/bf02246288

23 October 2019

exact match

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cites work

A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

The psychological and physiological effects of MDMA on normal volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Amphetamine intoxication with coagulopathy, hyperthermia, and reversible renal failure. A syndrome resembling heatstroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

A comparison of testing procedures on the discriminative morphine stimulus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Evidence concerning the involvement of 5-hydroxytryptamine in the locomotor activity produced by amphetamine or tranylcypromine plus L-DOPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Subjective reports of the effects of MDMA in a clinical setting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Second thoughts on 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Rhabdomyolysis and shock after intravenous amphetamine administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

21 January 2018

The serotonin syndrome

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

Hyperthermia and the amphetamine aggregation phenomenon: absence of a causal relation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02246288

L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats

21 January 2018

1 reference

12 December 2020

The N-methyl-D-aspartate (NMDA) receptor antagonist, dextrorphan, prevents the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats

1 reference

12 December 2020

Adrenal and striatal tyrosine hydroxylase activity after methamphetamine.

1 reference

12 December 2020

Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan

1 reference

12 December 2020

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain

1 reference

12 December 2020

Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems

1 reference

12 December 2020

Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

1 reference

12 December 2020

The complications of 'ecstasy' (MDMA)

1 reference

12 December 2020

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue

1 reference

12 December 2020

Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate.

1 reference

12 December 2020

MDMA: historical perspectives

1 reference

12 December 2020

A proposed new nomenclature for 5-HT receptors.

1 reference

12 December 2020

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine

1 reference

12 December 2020

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa

1 reference

12 December 2020

Factors influencing the toxicity of sympathomimetic amines to solitary mice

1 reference

12 December 2020

Inhibition of dopamine release by methylenedioxymethamphetamine is mediated by serotonin.

1 reference

12 December 2020

Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

1 reference

12 December 2020

Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

1 reference

12 December 2020

Ecstasy, the serotonin syndrome, and neuroleptic malignant syndrome--a possible link?

1 reference

12 December 2020

Psychiatric symptoms in cannabis users

1 reference

12 December 2020

MK-801 protects against amphetamine-induced striatal dopamine depletion in iprindole-treated rats, but not against brain serotonin depletion after p-chloroamphetamine administration

1 reference

12 December 2020

(+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats

1 reference

12 December 2020

Acute renal failure after ecstasy

1 reference

12 December 2020

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain.

1 reference

12 December 2020

'Rave' scene, ecstasy use, leap atlantic

1 reference

12 December 2020

Subjective effects of 3,4-methylenedioxymethamphetamine in recreational users.

1 reference

12 December 2020

Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain.

1 reference

12 December 2020

1 reference

12 December 2020

Can drugs be used to enhance the psychotherapeutic process?

1 reference

12 December 2020

The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei.

1 reference

12 December 2020

Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats

1 reference

12 December 2020

Prevalence and incidence of schizophrenia in Afro-Caribbeans

1 reference

12 December 2020

1 reference

12 December 2020

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat

1 reference

12 December 2020

Diversity of psychopathology associated with use of 3,4-methylenedioxymethamphetamine ('Ecstasy')

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys

1 reference

12 December 2020

Chlormethiazole and dizocilpine block the behavioural, but not the neurotoxic effects of 5,7-dihydroxytryptamine in mice

1 reference

12 December 2020

Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse

1 reference

12 December 2020

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.

1 reference

12 December 2020

Aminergic Metabolites in Cerebrospinal Fluid of Humans Previously Exposed to MDMA: Preliminary Observations

1 reference

12 December 2020

Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones.

1 reference

12 December 2020

Psychosis and cannabis abuse in The Gambia. A case-control study.

1 reference

12 December 2020

Amphetamine toxicity in aggregated mice

1 reference

12 December 2020

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1 reference

12 December 2020

"Ecstasy" (MDMA)-induced panic.

1 reference

12 December 2020

Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").

1 reference

12 December 2020

'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA

1 reference

12 December 2020

Accidental ingestion of 'Ecstasy' (3,4-methylenedioxymethylamphetamine)

1 reference

12 December 2020

Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations

1 reference

12 December 2020

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

1 reference

12 December 2020

MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.

1 reference

12 December 2020

Ecstasy and dantrolene

1 reference

12 December 2020

Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramine

1 reference

12 December 2020

Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals.

1 reference

12 December 2020

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.

1 reference

12 December 2020

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1 reference

12 December 2020

Persistent effects of (+/- )3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on human sleep.

1 reference

12 December 2020

Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys

1 reference

12 December 2020

Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.

1 reference

12 December 2020

‘Ecstasy’ Psychosis and Flashbacks

1 reference

12 December 2020

Effect of MK-801 on the decrease in tryptophan hydroxylase induced by methamphetamine and its methylenedioxy analog

1 reference

12 December 2020

Fenfluramine: evidence for a neurotoxic action on midbrain and a long-term depletion of serotonin

1 reference

12 December 2020

The action of some amines related to adrenaline. Cyclohexylalkylamines

1 reference

12 December 2020

Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats.

1 reference

12 December 2020

Incidence of recreational use of 3,4-methylenedimethoxymethamphetamine (MDMA, "ecstasy") on an undergraduate campus

1 reference

12 December 2020

[3H]3,4-methylenedioxymethamphetamine (MDMA) interactions with brain membranes and glass fiber filter paper

1 reference

12 December 2020

A case of MAO inhibitor/MDMA interaction: agony after ecstasy

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors

1 reference

12 December 2020

Neurochemical and behavioral effects of systematic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

1 reference

12 December 2020

5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents.

1 reference

12 December 2020

Hyperpyrexia induced by 3,4-methylenedioxyamphetamine ("Eve")

1 reference

12 December 2020

A growing industry and menace: makeshift laboratory's designer drugs.

1 reference

12 December 2020

Neurotoxicity of MDMA and related compounds: anatomic studies

1 reference

12 December 2020

Chronic atypical psychosis associated with MDMA ("ecstasy") abuse

1 reference

12 December 2020

Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

1 reference

12 December 2020

'Ecstasy' and intracerebral haemorrhage

1 reference

12 December 2020

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1 reference

12 December 2020

Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats

1 reference

12 December 2020

Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')

1 reference

12 December 2020

5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates

1 reference

12 December 2020

Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine

1 reference

12 December 2020

Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate.

1 reference

12 December 2020

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat.

1 reference

12 December 2020

The interactions of MK-801 with the amphetamine analogues D-methamphetamine (D-METH), 3,4-methylenedioxymethamphetamine (D-MDMA) or D-fenfluramine (D-FEN): neural damage and neural protection.

1 reference

12 December 2020

Ecstasy, 3–4 Methylenedioxymethamphetamine (MDMA), a Fatality Associated with Coagulopathy and Hyperthermia

1 reference

12 December 2020

Another death from Ecstacy

1 reference

12 December 2020

Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

1 reference

12 December 2020

Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology

1 reference

12 December 2020

Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites

1 reference

12 December 2020

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats

1 reference

12 December 2020

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.

1 reference

12 December 2020

The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole

1 reference

12 December 2020

The striatum and substantia nigra: A commentary on their relationships

1 reference

12 December 2020

Aggregation as a factor influencing the toxicity of sympathomimetic amines in mice

1 reference

12 December 2020

Single and repeated administration of neuroleptic drugs to rats: Effects on striatal dopamine-sensitive adenylate cyclase and locomotor activity produced by tranylcypromine and L-tryptophan or L-dopa

1 reference

12 December 2020

Lasting neuropsychiatric sequelae of (+-)methylenedioxymethamphetamine ('ecstasy') in recreational users

1 reference

12 December 2020

Neurotoxicity creates regulatory dilemma.

1 reference

12 December 2020

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.

1 reference

12 December 2020

Reinforcing subjective effects of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") may be separable from its neurotoxic actions: clinical evidence.

1 reference

12 December 2020

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors.

1 reference

12 December 2020

Subchronic methamphetamine treatment enhances methamphetamine- or cocaine-induced dopamine efflux in vivo.

1 reference

12 December 2020

Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1 reference

12 December 2020

Ecstasy and dantrolene

1 reference

12 December 2020

Chronic paranoid psychosis after misuse of MDMA ("ecstasy")

1 reference

12 December 2020

The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).

1 reference

12 December 2020

Ecstasy-fueled 'rave' parties become dances of death for English youths.

1 reference

12 December 2020

Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue

1 reference

12 December 2020

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1 reference

12 December 2020

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1 reference

12 December 2020

5,6-Dihydroxytryptamine, a serotonergic neurotoxin, is formed endogenously in the rat brain

1 reference

12 December 2020

Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain

1 reference

12 December 2020

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1 reference

12 December 2020

Schizophrenia in the Afro-Caribbean community.

1 reference

12 December 2020

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Chronic paranoid psychosis after misuse of MDMA

1 reference

12 December 2020

Psychiatric illness associated with "ecstasy".

1 reference

12 December 2020

Neurotoxicity of MDMA: neurochemical effects

1 reference

12 December 2020

Ecstasy and the dance of death

1 reference

12 December 2020

Ecstasy: towards an understanding of the biochemical basis of the actions of MDMA

1 reference

12 December 2020

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse

1 reference

12 December 2020

An overdose of ecstasy. A role for dantrolene

1 reference

12 December 2020

Reversible and irreversible phases of serotonin depletion by 4-chloroamphetamine

1 reference

12 December 2020

Hyperthermia in d-amphetamine toxicity in aggregated mice of different strains.

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1 reference

12 December 2020

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

1 reference

12 December 2020

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

12 December 2020

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1 reference

12 December 2020

Subarachnoid haemorrhage associated with MDMA abuse

1 reference

12 December 2020

Interactions of 5-hydroxytryptamine with oxidative enzymes

1 reference

12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

12 December 2020

Relationship of the structure of mescaline and seven analogs to toxicity and behavior in five species of laboratory animals

1 reference

12 December 2020

Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine.

1 reference

12 December 2020

The NMDA receptor antagonist MK-801 does not protect against serotonin depletions caused by high doses of DL-fenfluramine

1 reference

12 December 2020

1 reference

12 December 2020

Characterization of [3H]paroxetine binding to rat cortical membranes.

1 reference

12 December 2020

(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02246288

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7675958%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

23 October 2019

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