Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model (Q40379114)

20 September 2017

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model (English)

1 reference

20 September 2017

0 references

3

Edward Rockenstein

1 reference

20 September 2017

8

Eliezer Masliah

1 reference

20 September 2017

6

Fred H Gage

1 reference

20 September 2017

Oded Singer

1

1 reference

20 September 2017

Robert A Marr

2

1 reference

20 September 2017

Leslie Crews

4

1 reference

20 September 2017

Nicole G Coufal

5

1 reference

20 September 2017

Inder M Verma

7

1 reference

20 September 2017

language of work or name

English

0 references

publication date

28 August 2005

1 reference

20 September 2017

1 reference

20 September 2017

8

1 reference

20 September 2017

10

1 reference

20 September 2017

1343-1349

1 reference

https://scigraph.springernature.com/pub.10.1038/nn1531

20 September 2017

0 references

cites work

APP processing and synaptic function

1 reference

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

Emerging Alzheimer's disease therapies: inhibition of beta-secretase

21 January 2018

1 reference

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

1 reference

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

21 January 2018

1 reference

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

21 January 2018

1 reference

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease

21 January 2018

1 reference

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

21 January 2018

1 reference

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

21 January 2018

1 reference

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

1 reference

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

1 reference

Gene therapy for neurological disease

21 January 2018

1 reference

Molecular medicine for the brain: silencing of disease genes with RNA interference

21 January 2018

1 reference

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

21 January 2018

1 reference

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

21 January 2018

1 reference

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.

21 January 2018

1 reference

C-terminal fragment of amyloid precursor protein inhibits calcium uptake into rat brain microsomes by Mg2+-Ca2+ ATPase.

21 January 2018

1 reference

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

1 reference

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

21 January 2018

1 reference

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

21 January 2018

1 reference

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

21 January 2018

1 reference

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2.

21 January 2018

1 reference

Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

21 January 2018

1 reference

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

21 January 2018

1 reference

The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance.

21 January 2018

1 reference

Recent advances in the understanding of the processing of APP to beta amyloid peptide.

21 January 2018

1 reference

7 January 2021

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

1 reference

7 January 2021

Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice.

1 reference

7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

1 reference

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

7 January 2021

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

1 reference

7 January 2021

Identifiers

DOI

10.1038/NN1531

1 reference

Dimensions Publication ID

20 September 2017

0 references

1 reference