Phorbol-12-myristate-13-acetate-induced protein 1 (Q3879131)

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mammalian protein found in Homo sapiens

immediate-early-response protein APR
adult T cell leukemia-derived PMA-responsive
phorbol-12-myristate-13-acetate-induced protein 1
PMA-induced protein 1
PMAIP1
protein Noxa

Language	Label	Description	Also known as
English	Phorbol-12-myristate-13-acetate-induced protein 1	mammalian protein found in Homo sapiens	immediate-early-response protein APR adult T cell leukemia-derived PMA-responsive phorbol-12-myristate-13-acetate-induced protein 1 PMA-induced protein 1 PMAIP1 protein Noxa

Statements

1 reference

13 November 2019

UniProt protein ID

Phorbol-12-myristate-13-acetate-induced protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13794

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

7 references

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

mitochondrial outer membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

determination method

5 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13794&geneProductId=UniProtKB:Q13794

determination method

27 March 2018

BOK and NOXA are essential mediators of p53-dependent apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13794&geneProductId=UniProtKB:Q13794

determination method

27 March 2018

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13794&geneProductId=UniProtKB:Q13794

determination method

27 March 2018

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13794&geneProductId=UniProtKB:Q13794

determination method

27 March 2018

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13794&geneProductId=UniProtKB:Q13794

determination method

determination method

1 reference

8 April 2019

Noxa in colorectal cancer: a study on DNA, mRNA and protein expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

BOK and NOXA are essential mediators of p53-dependent apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

biological process

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

response to dsRNA

determination method

1 reference

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

cellular response to glucose starvation

determination method

1 reference

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of glucose metabolic process

determination method

1 reference

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

regulation of mitochondrial membrane permeability

determination method

1 reference

8 April 2019

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

defense response to virus

determination method

1 reference

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of protein oligomerization

determination method

1 reference

8 April 2019

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of release of cytochrome c from mitochondria

determination method

5 references

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

proteasomal protein catabolic process

determination method

1 reference

8 April 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

cellular response to hypoxia

determination method

release of cytochrome c from mitochondria

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

intrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

apoptotic process

determination method

3 references

regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

negative regulation of mitochondrial membrane potential

determination method

1 reference

8 April 2019

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

T cell homeostasis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of apoptotic process

determination method

3 references

8 April 2019

Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

8 April 2019

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of DNA damage response, signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

BOK and NOXA are essential mediators of p53-dependent apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

intrinsic apoptotic signaling pathway by p53 class mediator

determination method

1 reference

8 April 2019

BOK and NOXA are essential mediators of p53-dependent apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13794

determination method

Gene Atlas image

PBB GE PMAIP1 204286 s at fs.png
732 × 530; 11 KB

0 references

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000269518

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000269518

ENSP00000326119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000326119

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

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