Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease. (Q38578250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

S Lovestone

series ordinal

1

1 reference

4 September 2017

1 June 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

Dialogues in Clinical Neuroscience

15 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

2

1 reference

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15 January 2020

issue

2

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15 January 2020

page(s)

101-110

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

The presenilins in Alzheimer's disease--proteolysis holds the key.

15 January 2020

cites work

1 reference

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6 September 2017

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Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17.

6 September 2017

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Intracellular APP processing and A beta production in Alzheimer disease

6 September 2017

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Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

6 September 2017

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6 September 2017

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6 September 2017

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Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

6 September 2017

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Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

6 September 2017

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6 September 2017

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The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

6 September 2017

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

6 September 2017

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Evidence for a physical interaction between presenilin and Notch

6 September 2017

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

6 September 2017

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

6 September 2017

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

6 September 2017

1 reference

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Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

6 September 2017

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Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein

6 September 2017

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Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization

6 September 2017

1 reference

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

6 September 2017

1 reference

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

6 September 2017

1 reference

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

6 September 2017

1 reference

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

6 September 2017

1 reference

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The presenilin genes: a new gene family involved in Alzheimer disease pathology

6 September 2017

1 reference

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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

6 September 2017

1 reference

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A molecular mechanism for the effect of lithium on development

6 September 2017

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Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

6 September 2017

1 reference

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

6 September 2017

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

6 September 2017

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Isoform-specific binding of apolipoprotein E to beta-amyloid

6 September 2017

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Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

6 September 2017

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

6 September 2017

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

6 September 2017

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Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

6 September 2017

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ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

6 September 2017

1 reference

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Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor

6 September 2017

1 reference

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

6 September 2017

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

6 September 2017

1 reference

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Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region

6 September 2017

1 reference

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APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.

6 September 2017

1 reference

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Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis

6 September 2017

1 reference

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The role of beta-catenin stability in mutant PS1-associated apoptosis

14 September 2017

1 reference

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Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

27 September 2017

1 reference

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A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

27 September 2017

1 reference

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The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

27 September 2017

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

27 September 2017

1 reference

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

27 September 2017

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A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

27 September 2017

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Presenilin 1 interaction in the brain with a novel member of the Armadillo family

27 September 2017

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

27 September 2017

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The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

27 September 2017

1 reference

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Notch and Wingless signals collide

27 September 2017

1 reference

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Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases

27 September 2017

1 reference

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Notch: neurogenesis is only part of the picture

27 September 2017

1 reference

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27 September 2017

The Alzheimer diseases

1 reference

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Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts.

27 September 2017

1 reference

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

27 September 2017

1 reference

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The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

27 September 2017

1 reference

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

27 September 2017

1 reference

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Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

23 June 2018

1 reference

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Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.

23 June 2018

1 reference

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Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies.

23 June 2018

1 reference

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Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Abeta production in human primary neuron cultures.

23 June 2018

1 reference

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Amyloid fibrils may be assembled from beta-helical protofibrils

23 June 2018

1 reference

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Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts

23 June 2018

1 reference

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

23 June 2018

1 reference

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The ins and outs of notch signaling

23 June 2018

1 reference

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Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

23 June 2018

1 reference

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Presenilins and early-onset familial Alzheimer's disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.

23 June 2018

1 reference

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The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

23 June 2018

1 reference

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Microtubule assembly competence analysis of freshly-biopsied human tau, dephosphorylated tau, and Alzheimer tau.

23 June 2018

1 reference

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Immunohistochemical analysis of presenilin-1 expression in the mouse brain.

23 June 2018

1 reference

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Inhibition of beta-amyloid production by activation of protein kinase C.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Receptor-coupled amyloid precursor protein processing

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

23 June 2018

1 reference

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Diabetes and dementia: is the brain another site of end-organ damage?

23 June 2018

1 reference

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Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons.

31 August 2018

1 reference

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Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684.

31 August 2018

1 reference

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Neuropathological changes in the nucleus basalis correlate with clinical measures of dementia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

31 August 2018

Notch and neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Evolution of neuronal changes in the course of Alzheimer's disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Human apolipoprotein E accelerates microtubule polymerization in vitro.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Intraneuronal compartments of the amyloid precursor protein.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Notch is required for wingless signaling in the epidermis of Drosophila.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181594

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

31 August 2018

1 reference

12 December 2020

Low frequency of the APP 670/671 mutation in familial Alzheimer's disease in Sweden

1 reference

12 December 2020

Molecular Genetics of Alzheimer's Disease

1 reference

12 December 2020

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

1 reference

12 December 2020

The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

1 reference

12 December 2020

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

1 reference

12 December 2020

Alzheimer's disease: amyloid plaques in the cerebellum

1 reference

12 December 2020

FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10

1 reference

12 December 2020

An analysis of the morphology of senile plaques in Down's syndrome patients of different ages using immunocytochemical and lectin histochemical techniques

1 reference

12 December 2020

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

1 reference

12 December 2020

The genetics of Alzheimer's disease

1 reference

12 December 2020

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1 reference

12 December 2020

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22033981%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference