Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2. (Q38321163)

2 September 2017

Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2. (English)

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Human T-lymphotropic virus 1

2 September 2017

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H U Park

1

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2 September 2017

S-J Jeong

2

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2 September 2017

J-H Jeong

3

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2 September 2017

J H Chung

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2 September 2017

J N Brady

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2 September 2017

language of work or name

English

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publication date

1 January 2006

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2 September 2017

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2 September 2017

25

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2 September 2017

3

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2 September 2017

438-447

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209059

2 September 2017

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cites work

The Chk2 protein kinase

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Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein

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HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

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Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Regulation of gene expression by HTLV-I Tax protein

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Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets

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Enhanced metallothionein gene expression is associated with protection from cadmium-induced genotoxicity in cultured rat liver cells

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Cadmium-induced DNA strand damage in cultured liver cells: reduction in cadmium genotoxicity following zinc pretreatment

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Molecular mechanism of tumorigenesis in mice transgenic for the human T cell leukemia virus Tax gene

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Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector

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Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

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The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells

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Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

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A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.

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HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity

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Molecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).

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Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein

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7 January 2021

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

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Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines.

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7 January 2021

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

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Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

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7 January 2021

Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1.

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7 January 2021

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

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Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.

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Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent.

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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

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Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model

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The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors

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7 January 2021

Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone

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7 January 2021

Determination of substrate specificity and putative substrates of Chk2 kinase

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7 January 2021

New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen

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7 January 2021

Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis

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7 January 2021

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

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7 January 2021

Chk2 activates E2F-1 in response to DNA damage

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7 January 2021

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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7 January 2021

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

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7 January 2021

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

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7 January 2021

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

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7 January 2021

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

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7 January 2021

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209059

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Dimensions Publication ID

2 September 2017

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