On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies (Q37856642)

24 August 2017

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title

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies (English)

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24 August 2017

3

J-M Taymans

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24 August 2017

V Daniëls

1

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PubMed ID

21430363

24 August 2017

V Baekelandt

series ordinal

2

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24 August 2017

23 March 2011

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24 August 2017

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24 August 2017

19

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24 August 2017

1

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24 August 2017

1-15

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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

24 August 2017

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

21 January 2018

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 January 2018

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

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GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

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Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

21 January 2018

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Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

21 January 2018

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Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

21 January 2018

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LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

21 January 2018

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

21 January 2018

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The WD40 domain is required for LRRK2 neurotoxicity

21 January 2018

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

21 January 2018

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

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The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.

21 January 2018

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LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

21 January 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

21 January 2018

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

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LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

21 January 2018

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

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Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions

21 January 2018

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

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Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

21 January 2018

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Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

21 January 2018

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

21 January 2018

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Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

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14-3-3 proteins are promising LRRK2 interactors

21 January 2018

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A comparative study of Lrrk2 function in primary neuronal cultures

21 January 2018

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I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

21 January 2018

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Identification of potential protein interactors of Lrrk2

21 January 2018

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

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Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

21 January 2018

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The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

21 January 2018

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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

21 January 2018

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Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease

21 January 2018

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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

21 January 2018

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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

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Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

21 January 2018

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ERM proteins in cell adhesion and membrane dynamics

21 January 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

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RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player

21 January 2018

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

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The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

21 January 2018

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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

21 January 2018

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

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LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

21 January 2018

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Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2.

21 January 2018

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CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

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Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

21 January 2018

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Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

21 January 2018

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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

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Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease

21 January 2018

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

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LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

21 January 2018

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

21 January 2018

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Investigating convergent actions of genes linked to familial Parkinson's disease.

21 January 2018

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LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

21 January 2018

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Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

21 January 2018

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Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

21 January 2018

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A Drosophila model for LRRK2-linked parkinsonism

21 January 2018

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Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

21 January 2018

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 January 2018

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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

21 January 2018

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000324488

1 reference

24 August 2017

1 reference

PubMed ID

21430363