From evolutionary genetics to human immunology: how selection shapes host defence genes (Q37642585)

21 August 2017

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title

From evolutionary genetics to human immunology: how selection shapes host defence genes (English)

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21 August 2017

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2

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21 August 2017

Luis B Barreiro

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publication date

1 December 2009

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21 August 2017

Nature Reviews Genetics

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21 August 2017

11

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21 August 2017

1

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21 August 2017

17-30

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https://scigraph.springernature.com/pub.10.1038/nrg2698

21 August 2017

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More genes underwent positive selection in chimpanzee evolution than in human evolution

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Copy number variation of CCL3-like genes affects rate of progression to simian-AIDS in Rhesus Macaques (Macaca mulatta)

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Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites

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Molecular evolution of GYPC: evidence for recent structural innovation and positive selection in humans

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A map of recent positive selection in the human genome

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Global landscape of recent inferred Darwinian selection for Homo sapiens

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Origins of major human infectious diseases

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Widespread balancing selection and pathogen-driven selection at blood group antigen genes

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Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

31 March 2020

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Pathogen-Driven Selection and Worldwide HLA Class I Diversity

31 March 2020

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Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

31 March 2020

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Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes

31 March 2020

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A strong signature of balancing selection in the 5' cis-regulatory region of CCR5.

31 March 2020

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The geographic spread of the CCR5 Delta32 HIV-resistance allele

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The case for selection at CCR5-Delta32

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The population genetics of the haemoglobinopathies

31 March 2020

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Haemoglobin C protects against clinical Plasmodium falciparum malaria

31 March 2020

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Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection

31 March 2020

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Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion

31 March 2020

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Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals

31 March 2020

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Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus

31 March 2020

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Complex signatures of natural selection at the Duffy blood group locus

31 March 2020

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Malaria susceptibility and CD36 mutation

31 March 2020

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31 March 2020

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CD40L association with protection from severe malaria

31 March 2020

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A haplotype map of the human genome

31 March 2020

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Detecting recent positive selection in the human genome from haplotype structure

31 March 2020

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Molecular analysis of the beta-globin gene cluster in the Niokholo Mandenka population reveals a recent origin of the beta(S) Senegal mutation

31 March 2020

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Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance

31 March 2020

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Early origin and recent expansion of Plasmodium falciparum

31 March 2020

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A polytene chromosome analysis of the Anopheles gambiae species complex

31 March 2020

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Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles

31 March 2020

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Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection

31 March 2020

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Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature

31 March 2020

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Searching for signals of evolutionary selection in 168 genes related to immune function.

31 March 2020

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Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency

31 March 2020

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

31 March 2020

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A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

31 March 2020

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A history of recurrent positive selection at the toll-like receptor 5 in primates

31 March 2020

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A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus

31 March 2020

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

31 March 2020

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TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

31 March 2020

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When less is more: gene loss as an engine of evolutionary change

31 March 2020

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Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians

31 March 2020

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Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.

31 March 2020

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Spread of an inactive form of caspase-12 in humans is due to recent positive selection

31 March 2020

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A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs

31 March 2020

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

31 March 2020

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The inflammatory caspases: guardians against infections and sepsis

31 March 2020

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Copy number variation and evolution in humans and chimpanzees

31 March 2020

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Natural selection on genes that underlie human disease susceptibility

31 March 2020

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Darwinian and demographic forces affecting human protein coding genes

31 March 2020

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

31 March 2020

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Pyogenic bacterial infections in humans with MyD88 deficiency

31 March 2020

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TLR3 deficiency in patients with herpes simplex encephalitis

31 March 2020

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Human genetics of infectious diseases: a unified theory

31 March 2020

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Population genetics models of common diseases

31 March 2020

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Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease

31 March 2020

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Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction

31 March 2020

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Signals of recent positive selection in a worldwide sample of human populations

31 March 2020

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Revealing the architecture of gene regulation: the promise of eQTL studies

31 March 2020

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Modifier effects between regulatory and protein-coding variation

31 March 2020

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Population genomics of human gene expression

31 March 2020

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Gene expression levels are a target of recent natural selection in the human genome

31 March 2020

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Common regulatory variation impacts gene expression in a cell type-dependent manner

31 March 2020

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A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease

31 March 2020

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Innate immune recognition

31 March 2020

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Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

31 March 2020

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Toll-like receptors and innate immunity

31 March 2020

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Toll-like receptors--taking an evolutionary approach

31 March 2020

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Innate immune recognition of viral infection

31 March 2020

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Self- and nonself-recognition by C-type lectins on dendritic cells

31 March 2020

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Nod-like proteins in immunity, inflammation and disease

31 March 2020

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Recognition of viruses by innate immunity.

31 March 2020

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Autoreactivity by design: innate B and T lymphocytes

31 March 2020

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Discovering the role of the major histocompatibility complex in the immune response

31 March 2020

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Fundamental concepts in genetics: Genetics and the understanding of selection

31 March 2020

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Molecular signatures of natural selection

31 March 2020

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Methods to detect selection in populations with applications to the human

31 March 2020

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High genomic deleterious mutation rates in hominids

31 March 2020

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Most rare missense alleles are deleterious in humans: implications for complex disease and association studies

31 March 2020

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The signature of positive selection on standing genetic variation

31 March 2020

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Balancing selection and its effects on sequences in nearby genome regions

31 March 2020

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Adaptive protein evolution at the Adh locus in Drosophila

31 March 2020

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Statistical methods for detecting molecular adaptation

31 March 2020

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Control of the False Discovery Rate Applied to the Detection of Positively Selected Amino Acid Sites

31 March 2020

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Progress and prospects in mapping recent selection in the genome.

31 March 2020

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Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems

31 March 2020

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KIR: diverse, rapidly evolving receptors of innate and adaptive immunity

31 March 2020

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Understanding how combinations of HLA and KIR genes influence disease

31 March 2020

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Unusual selection on the KIR3DL1/S1 natural killer cell receptor in africans

31 March 2020

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Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria

31 March 2020

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12 December 2020

Polymorphism and balancing selection at major histocompatibility complex loci

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12 December 2020

Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression

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12 December 2020

Nucleotide variability at G6pd and the signature of malarial selection in humans.

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12 December 2020

Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene

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12 December 2020

Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S.

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12 December 2020

Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans

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12 December 2020

Identifiers

DOI

10.1038/NRG2698

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PubMed ID

19953080

Dimensions Publication ID

21 August 2017

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1 reference

PubMed ID

19953080