Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics (Q37564619)

21 August 2017

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics (English)

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Carsten Schultz-Fademrecht

21 August 2017

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12

object named as

Carsten Schultz-Fademrecht

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21 August 2017

Jeffery Chakedis

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21 August 2017

Randall French

2

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Michele Babicky

3

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21 August 2017

Dawn Jaquish

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21 August 2017

Evangeline Mose

5

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21 August 2017

Peter Cheng

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21 August 2017

Patrick Holman

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Haleigh Howard

8

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21 August 2017

Jaclyn Miyamoto

9

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21 August 2017

Paula Porras

10

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Zakk Walterscheid

11

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Christina Esdar

13

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21 August 2017

Oliver Schadt

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Jan Eickhoff

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21 August 2017

Andrew M Lowy

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21 August 2017

language of work or name

English

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publication date

14 June 2016

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21 August 2017

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7

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45959-45975

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describes a project that uses

21 August 2017

DESeq2

object named as

DESeq

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells

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RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

23 August 2017

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Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets

23 August 2017

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Effect of DAPK1 gene on proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line.

23 August 2017

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BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function

23 August 2017

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Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

23 August 2017

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Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma

23 August 2017

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23 August 2017

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Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi)

23 August 2017

1 reference

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The future of epigenetic therapy in solid tumours--lessons from the past.

23 August 2017

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Landscape of transcription in human cells

23 August 2017

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Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

23 August 2017

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Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase

23 August 2017

1 reference

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The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells

23 August 2017

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Alternative splicing and evolution: diversification, exon definition and function

23 August 2017

1 reference

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The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily

23 August 2017

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

23 August 2017

1 reference

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Alternative isoform regulation in human tissue transcriptomes

23 August 2017

1 reference

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Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype

23 August 2017

1 reference

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Constitutive activation of the RON gene promotes invasive growth but not transformation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype

23 August 2017

1 reference

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Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

23 August 2017

1 reference

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Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

6 September 2017

1 reference

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Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents

6 September 2017

1 reference

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Spatial control of EGF receptor activation by reversible dimerization on living cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Characterizing DNA methylation patterns in pancreatic cancer genome.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216774

An in vivo platform for translational drug development in pancreatic cancer

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27323855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypermethylation of Ron proximal promoter associates with lack of full-length Ron and transcription of oncogenic short-Ron from an internal promoter

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27323855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.10009

1 reference

21 August 2017

1 reference

21 August 2017

1 reference