Type 2 diabetes: new genes, new understanding (Q37308665)

19 August 2017

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title

Type 2 diabetes: new genes, new understanding (English)

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19 August 2017

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19 August 2017

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Cecilia M Lindgren

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Mark McCarthy

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Mark I McCarthy

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2

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publication date

25 October 2008

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19 August 2017

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19 August 2017

12

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19 August 2017

613-621

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

19 August 2017

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12 December 2020

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

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12 December 2020

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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12 December 2020

Global and societal implications of the diabetes epidemic

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12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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12 December 2020

Growing evidence for diabetes susceptibility genes from genome scan data

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12 December 2020

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

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12 December 2020

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

Candidate genes for type 2 diabetes

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12 December 2020

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

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12 December 2020

Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

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12 December 2020

MicroRNA-143 regulates adipocyte differentiation

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12 December 2020

A pancreatic islet-specific microRNA regulates insulin secretion

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12 December 2020

Type 2 diabetes: principles of pathogenesis and therapy

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12 December 2020

What makes a good genetic association study?

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12 December 2020

A haplotype map of the human genome

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12 December 2020

An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets

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12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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12 December 2020

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

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12 December 2020

Wolfram/DIDMOAD syndrome, a heterogenic and molecularly complex neurodegenerative disease.

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12 December 2020

Evaluating and improving power in whole-genome association studies using fixed marker sets.

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12 December 2020

Evaluating coverage of genome-wide association studies

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12 December 2020

MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells

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12 December 2020

Highly parallel genomic assays

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12 December 2020

Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

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12 December 2020

p16INK4a induces an age-dependent decline in islet regenerative potential

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12 December 2020

Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE

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12 December 2020

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

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12 December 2020

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

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12 December 2020

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

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12 December 2020

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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12 December 2020

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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12 December 2020

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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12 December 2020

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

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12 December 2020

MicroRNAs in skeletal and cardiac muscle development

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12 December 2020

A common variant on chromosome 9p21 affects the risk of myocardial infarction

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12 December 2020

A common allele on chromosome 9 associated with coronary heart disease

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12 December 2020

Genetic prediction of future type 2 diabetes

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12 December 2020

A new multipoint method for genome-wide association studies by imputation of genotypes

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12 December 2020

Copy-number variation and association studies of human disease

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12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

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12 December 2020

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

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12 December 2020

Genomewide association analysis of coronary artery disease

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12 December 2020

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

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12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

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12 December 2020

The common biology of cancer and ageing

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12 December 2020

Genome-wide association studies provide new insights into type 2 diabetes aetiology

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12 December 2020

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

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12 December 2020

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

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12 December 2020

Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies

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12 December 2020

A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array

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12 December 2020

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations

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12 December 2020

A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets

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12 December 2020

Population genomics of human gene expression

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12 December 2020

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

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12 December 2020

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

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12 December 2020

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.

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12 December 2020

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

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12 December 2020

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

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12 December 2020

Multiple loci identified in a genome-wide association study of prostate cancer

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12 December 2020

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

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12 December 2020

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

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12 December 2020

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

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12 December 2020

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

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12 December 2020

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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12 December 2020

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

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12 December 2020

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

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12 December 2020

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population

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12 December 2020

Large recurrent microdeletions associated with schizophrenia

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12 December 2020

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

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12 December 2020

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

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12 December 2020

10.1016/J.TIG.2008.09.004

Identifiers

DOI

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19 August 2017

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PubMed ID

18952314