Cytochrome c: functions beyond respiration (Q37196132)

18 August 2017

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title

Cytochrome c: functions beyond respiration (English)

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18 August 2017

Douglas R Green

2

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author name string

Yong-Ling P Ow

series ordinal

1

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PubMed ID

18568041

18 August 2017

Zhenyue Hao

series ordinal

3

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PubMed ID

18568041

18 August 2017

Tak W Mak

series ordinal

4

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18 August 2017

1 July 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

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18 August 2017

9

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18 August 2017

7

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18 August 2017

532-542

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https://scigraph.springernature.com/pub.10.1038/nrm2434

18 August 2017

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cites work

The apoptosome: signalling platform of cell death

1 reference

Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death

31 March 2020

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A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis

31 March 2020

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

31 March 2020

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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

31 March 2020

1 reference

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

31 March 2020

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

31 March 2020

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Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

31 March 2020

1 reference

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

31 March 2020

1 reference

Injected cytochrome c induces apoptosis

31 March 2020

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Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

31 March 2020

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Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release

31 March 2020

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Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

31 March 2020

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A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1

31 March 2020

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Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

31 March 2020

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Comparative analysis of proapoptotic activity of cytochrome c mutants in living cells.

31 March 2020

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Role of cardiolipin in cytochrome c release from mitochondria

31 March 2020

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Multiple pathways of cytochrome c release from mitochondria in apoptosis

31 March 2020

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Cardiolipin: setting the beat of apoptosis

31 March 2020

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Cytochrome c impaled: investigation of the extended lipid anchorage of a soluble protein to mitochondrial membrane models

31 March 2020

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Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

31 March 2020

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A conformational switch to beta-sheet structure in cytochrome c leads to heme exposure. Implications for cardiolipin peroxidation and apoptosis

31 March 2020

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Mechanisms of cytochrome c release from mitochondria

31 March 2020

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Mitochondrial membrane permeabilization in cell death

31 March 2020

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A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.

31 March 2020

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Effect of cytochrome c on the generation and elimination of O2*- and H2O2 in mitochondria

31 March 2020

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Detoxifying function of cytochrome c against oxygen toxicity

31 March 2020

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Mitochondrial oxidative stress: implications for cell death

31 March 2020

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Mitochondrial Release of Pro-apoptotic Proteins

31 March 2020

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Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

31 March 2020

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

31 March 2020

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A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

31 March 2020

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31 March 2020

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Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

31 March 2020

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

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The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

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Bax-dependent regulation of Bak by voltage-dependent anion channel 2.

31 March 2020

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A tale of two mitochondrial channels, MAC and PTP, in apoptosis

31 March 2020

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Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

31 March 2020

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Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

31 March 2020

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Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

31 March 2020

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

31 March 2020

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Another piece of the puzzle of apoptotic cytochrome c release

31 March 2020

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VDAC2 inhibits BAK activation and mitochondrial apoptosis

31 March 2020

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Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

31 March 2020

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A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release.

31 March 2020

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The permeability transition pore in cell death

31 March 2020

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Mitochondrial ceramide and the induction of apoptosis

31 March 2020

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A mechanistic view of mitochondrial death decision pores.

31 March 2020

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Glycosphingolipids and mitochondria: role in apoptosis and disease.

31 March 2020

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Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition

31 March 2020

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Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis

31 March 2020

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The pathophysiology of mitochondrial cell death

31 March 2020

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Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

31 March 2020

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31 March 2020

At the gates of death.

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

31 March 2020

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The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

31 March 2020

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Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release

31 March 2020

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tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1.

31 March 2020

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Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis

31 March 2020

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Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2.

31 March 2020

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Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity

31 March 2020

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Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes

31 March 2020

1 reference

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

31 March 2020

1 reference

Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

31 March 2020

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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

31 March 2020

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Hsp27 as a negative regulator of cytochrome C release

31 March 2020

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

31 March 2020

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Hsp27 negatively regulates cell death by interacting with cytochrome c.

31 March 2020

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Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

31 March 2020

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

31 March 2020

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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

31 March 2020

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Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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ER stress triggers apoptosis by activating BH3-only protein Bim

31 March 2020

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A Conformational Change in Cytochromecof Apoptotic and Necrotic Cells Is Detected by Monoclonal Antibody Binding and Mimicked by Association of the Native Antigen with Synthetic Phospholipid Vesicles†

31 March 2020

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Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis

31 March 2020

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Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

31 March 2020

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Mitochondrial nitric oxide in the signaling of cell integrated responses

31 March 2020

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Nitrosylation of cytochrome c during apoptosis

31 March 2020

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Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation

31 March 2020

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Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

31 March 2020

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Histone H1.2 as a trigger for apoptosis

31 March 2020

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Dissecting p53-dependent apoptosis.

31 March 2020

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Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9

31 March 2020

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Laser micro-irradiation of mitochondria: is there an amplified mitochondrial death signal in neural cells?

31 March 2020

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GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

31 March 2020

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Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization

31 March 2020

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Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons.

31 March 2020

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The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

31 March 2020

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Cytochrome c-d regulates developmental apoptosis in the Drosophila retina

31 March 2020

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Adult Apaf-1-deficient mice exhibit male infertility

31 March 2020

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Role of mitochondria as the gardens of cell death

31 March 2020

1 reference

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

31 March 2020

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Apoptosis-inducing factor: vital and lethal

31 March 2020

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Apoptosis-inducing factor: a matter of neuron life and death

31 March 2020

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Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

31 March 2020

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Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

31 March 2020

1 reference

The mitochondrial permeability transition from in vitro artifact to disease target

31 March 2020

1 reference

Bax directly induces release of cytochrome c from isolated mitochondria

31 March 2020

1 reference

Stabilizers and Destabilizers Controlling Cell Cycle Oscillators

31 March 2020

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NFAT transcription factors in control of peripheral T cell tolerance.

31 March 2020

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Apoptosis of allospecifically activated human helper T cells is blocked by calcineurin inhibition.

31 March 2020

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Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair.

31 March 2020

1 reference

Apoptosome: a platform for the activation of initiator caspases

31 March 2020

1 reference

Caspase-2 is required for cell death induced by cytoskeletal disruption

31 March 2020

1 reference

Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM2434

1 reference

18 August 2017

1 reference

PubMed ID

18568041