In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. (Q37124209)

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scientific article published on 17 June 2013

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English	In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.	scientific article published on 17 June 2013

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scholarly article

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3 March 2020

In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi (English)

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Trypanosoma cruzi

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Constança Britto

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Maria de Nazaré Correia Soeiro

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3 March 2020

Elen Mello de Souza

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3 March 2020

Cristiane França da Silva

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Denise da Gama Jaen Batista

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Marcos Meuser Batista

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Beatriz Philot Pavão

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Julianna Siciliano Araújo

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Claudia Alessandra Fortes Aiub

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Patrícia Bernardino da Silva

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3 March 2020

Jessica Lionel

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Kwangho Kim

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Gary Sulikowski

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Tatiana Y Hargrove

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Michael R Waterman

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3 March 2020

Galina I Lepesheva

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17 June 2013

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3 March 2020

Antimicrobial Agents and Chemotherapy

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3 March 2020

57

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4151-4163

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3 March 2020

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

1 reference

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14 September 2017

VNI cures acute and chronic experimental Chagas disease

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14 September 2017

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

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14 September 2017

In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection

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14 September 2017

Vaccine development against Trypanosoma cruzi and Chagas disease.

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14 September 2017

Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)

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14 September 2017

Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies

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14 September 2017

Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis

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14 September 2017

Structural basis for conservation in the CYP51 family

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14 September 2017

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

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14 September 2017

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment

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Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus

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14 September 2017

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI.

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14 September 2017

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

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14 September 2017

CYP51: A major drug target in the cytochrome P450 superfamily

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3754355

14 September 2017

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

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14 September 2017

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

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History of the development of azole derivatives

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Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

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14 September 2017

Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

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14 September 2017

Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types

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14 September 2017

Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi

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14 September 2017

Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.

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27 June 2018

Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox

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27 June 2018

Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease

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27 June 2018

A novel triazolic naphthofuranquinone induces autophagy in reservosomes and impairment of mitosis in Trypanosoma cruzi.

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3 September 2018

In vitro and in vivo experimental models for drug screening and development for Chagas disease

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3 September 2018

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3 September 2018

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3 September 2018

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase

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4 December 2018

Use of a simplified polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area

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Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes

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The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi

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inferred from PubMed ID database lookup

Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi

1 reference

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based on heuristic

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1 reference

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inferred from PubMed ID database lookup

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10.1128/AAC.00070-13

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3 March 2020

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