Kinase signaling pathways as potential targets in the treatment of Parkinson's disease (Q37027503)

17 August 2017

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title

Kinase signaling pathways as potential targets in the treatment of Parkinson's disease (English)

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17 August 2017

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2

Andrew Singleton

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17 August 2017

1

Elisa Greggio

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17 August 2017

1 December 2007

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Expert Review of Proteomics

17 August 2017

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17 August 2017

4

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17 August 2017

6

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17 August 2017

783-792

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

17 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The protein kinase complement of the human genome

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The RIP kinases: crucial integrators of cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Biochemical and pathological characterization of Lrrk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Cell biology. Lessons in rational drug design for protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Leucine-rich repeat kinase 2 associates with lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkinson's disease: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Deciphering the role of heterozygous mutations in genes associated with parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Distribution of PINK1 and LRRK2 in rat and mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

DJ-1, a novel regulator of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRRK2 protein is a component of lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

Homozygous and heterozygous PINK1 mutations: Considerations for diagnosis and care of Parkinson's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.4.6.783

21 January 2018

Identifiers

DOI

10.1586/14789450.4.6.783

1 reference

17 August 2017

1 reference

PubMed ID

18067416