Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. (Q36916670)

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3 January 2020

review article

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title

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template (English)

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3 January 2020

3

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R Scott Williams

1

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author name string

Jessica S Williams

series ordinal

2

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publication date

1 August 2007

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Biochemistry and Cell Biology

3 January 2020

published in

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volume

85

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issue

4

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page(s)

509-520

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Cell cycle checkpoint signaling through the ATM and ATR kinases

3 January 2020

cites work

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DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

21 January 2018

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MRE11/RAD50/NBS1: complex activities

21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

21 January 2018

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

21 January 2018

1 reference

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

1 reference

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

21 January 2018

1 reference

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

21 January 2018

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Deletions at stalled replication forks occur by two different pathways

21 January 2018

1 reference

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.

21 January 2018

1 reference

Role of DNA-PK in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

Dimerization of the Rad50 protein is independent of the conserved hook domain.

21 January 2018

1 reference

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

1 reference

The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint

21 January 2018

1 reference

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair

21 January 2018

1 reference

Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

21 January 2018

1 reference

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

21 January 2018

1 reference

Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity

21 January 2018

1 reference

NuA4 subunit Yng2 function in intra-S-phase DNA damage response

21 January 2018

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The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA

21 January 2018

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Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

21 January 2018

1 reference

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

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DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

21 January 2018

1 reference

Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex

21 January 2018

1 reference

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

1 reference

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

21 January 2018

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Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

21 January 2018

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Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination

21 January 2018

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Interactions between BRCT repeats and phosphoproteins: tangled up in two

21 January 2018

1 reference

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.

21 January 2018

1 reference

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

1 reference

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

21 January 2018

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

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DNA double-strand break repair from head to tail

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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DNA breaks promote genomic instability by impeding proper chromosome segregation.

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin

21 January 2018

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A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.

21 January 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

21 January 2018

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

21 January 2018

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

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DNA double-strand breaks caused by replication arrest

21 January 2018

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ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex

21 January 2018

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The rad50 signature motif: essential to ATP binding and biological function

21 January 2018

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Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

21 January 2018

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INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

21 January 2018

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Altering nucleosomes during DNA double-strand break repair in yeast.

21 January 2018

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Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage.

21 January 2018

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A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

21 January 2018

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

21 January 2018

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Radiosensitization of head/neck squamous cell carcinoma by adenovirus-mediated expression of the Nbs1 protein

21 January 2018

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Interplay between human DNA repair proteins at a unique double-strand break in vivo

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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A chromatin remodelling complex involved in transcription and DNA processing.

21 January 2018

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Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

21 January 2018

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The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks

21 January 2018

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RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin

21 January 2018

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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

21 January 2018

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Structure and function of the double-strand break repair machinery.

21 January 2018

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Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

21 January 2018

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Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

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MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

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Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

21 January 2018

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The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

21 January 2018

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Chromosome segregation and double-strand break repair - a complex connection

21 January 2018

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Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.

21 January 2018

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 January 2018

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

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A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein

21 January 2018

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Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

21 January 2018

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 January 2018

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

21 January 2018

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DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

21 January 2018

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

21 January 2018

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Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

21 January 2018

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Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

21 January 2018

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DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain

21 January 2018

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Complex formation and functional versatility of Mre11 of budding yeast in recombination

21 January 2018

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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Regulation and mechanisms of mammalian double-strand break repair

21 January 2018

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Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

21 January 2018

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The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

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Chromosomal stability and the DNA double-stranded break connection

21 January 2018

1 reference

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

1 reference

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase

21 January 2018

1 reference

Molecular views of recombination proteins and their control

21 January 2018

1 reference

A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.

21 January 2018

1 reference

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

21 January 2018

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Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

21 January 2018

1 reference

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

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Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

21 January 2018

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

1 reference

Radioresistant DNA synthesis and human genetic diseases

21 January 2018

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The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae

21 January 2018

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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Chromosome Fragmentation after Induction of a Double-Strand Break Is an Active Process Prevented by the RMX Repair Complex

21 January 2018

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Double-strand breaks at an initiation site for meiotic gene conversion

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/O07-069

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17713585%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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