Nuclear bile acid receptor FXR as pharmacological target: are we there yet? (Q36564086)

14 August 2017

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title

Nuclear bile acid receptor FXR as pharmacological target: are we there yet? (English)

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14 August 2017

Salvatore Modica

1

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PubMed ID

16904670

14 August 2017

Antonio Moschetta

series ordinal

2

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PubMed ID

16904670

14 August 2017

language of work or name

English

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publication date

8 August 2006

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14 August 2017

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14 August 2017

580

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14 August 2017

23

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14 August 2017

5492-5499

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Orphan nuclear receptors--new ligands and new possibilities.

14 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Orphan nuclear receptors: shifting endocrinology into reverse

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The RXR heterodimers and orphan receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Retinoid x receptor heterodimers in the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The nuclear receptor superfamily: the second decade

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Identification of a nuclear receptor that is activated by farnesol metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Identification of a nuclear receptor for bile acids

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The continuing importance of bile acids in liver and intestinal disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The effects of cholestyramine on high density lipoprotein metabolism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Regulation of bile acid synthesis under reconstructed enterohepatic circulation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Glucose regulates the expression of the farnesoid X receptor in liver

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Transient impairment of the adaptive response to fasting in FXR-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Lack of intestinal bile results in delayed liver regeneration of normal rat liver after hepatectomy accompanied by impaired cyclin E-associated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Idiopathic bile acid catharsis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Identification of gene-selective modulators of the bile acid receptor FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

10.1016/J.FEBSLET.2006.07.082

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16904670