Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. (Q35823278)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22325991%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation (English)

1 reference

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Heterogeneous nuclear ribonucleoprotein U

22 January 2020

main subject

RNA sequencing

0 references

1 reference

GOA release 2020-03-11

pre-mRNA binding

1 reference

alternative mRNA splicing, via spliceosome

GOA release 2020-03-11

1 reference

4

1 reference

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22 January 2020

Yu Zhou

5

1 reference

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22 January 2020

Changwei Shao

6

1 reference

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22 January 2020

Yi Zhang

9

1 reference

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22 January 2020

author name string

Rui Xiao

1

1 reference

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22 January 2020

Peng Tang

2

1 reference

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22 January 2020

Bo Yang

3

1 reference

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22 January 2020

Hairi Li

7

1 reference

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22 January 2020

Hui Sun

8

1 reference

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22 January 2020

Xiang-Dong Fu

10

1 reference

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22 January 2020

publication date

9 February 2012

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22 January 2020

1 reference

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22 January 2020

volume

45

1 reference

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22 January 2020

issue

5

1 reference

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22 January 2020

page(s)

656-668

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Regulation of alternative splicing by the core spliceosomal machinery

22 January 2020

cites work

1 reference

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SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons

11 July 2018

1 reference

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iCLIP predicts the dual splicing effects of TIA-RNA interactions.

11 July 2018

1 reference

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A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.

11 July 2018

1 reference

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The matrix protein hnRNP U is required for chromosomal localization of Xist RNA.

11 July 2018

1 reference

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The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation

11 July 2018

1 reference

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Long noncoding RNA as modular scaffold of histone modification complexes

11 July 2018

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The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

11 July 2018

1 reference

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The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

11 July 2018

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Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping

11 July 2018

1 reference

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Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.

11 July 2018

1 reference

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Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

11 July 2018

1 reference

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An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles

11 July 2018

1 reference

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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

11 July 2018

1 reference

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

The splicing factor SC35 has an active role in transcriptional elongation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Coupling transcription and alternative splicing.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

An intronic element contributes to splicing repression in spinal muscular atrophy.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

hnRNP-U enhances the expression of specific genes by stabilizing mRNA.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Inhibition of HIV-1 gene expression by a fragment of hnRNP U.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

CAJAL BODIES: A Long History of Discovery

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Hypomorphic mutation in hnRNP U results in post-implantation lethality

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Actin and hnRNP U cooperate for productive transcription by RNA polymerase II.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Systematic identification and analysis of exonic splicing silencers.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A role for Cajal bodies in the final steps of U2 snRNP biogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A slow RNA polymerase II affects alternative splicing in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Essential role for the SMN complex in the specificity of snRNP assembly

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Comprehensive proteomic analysis of the human spliceosome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Large-scale proteomic analysis of the human spliceosome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Identification of a cis-acting element for the regulation of SMN exon 7 splicing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Spliceosomal UsnRNP biogenesis, structure and function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A mouse model for spinal muscular atrophy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Specific interaction of heterogeneous nuclear ribonucleoprotein particle U with the leader RNA sequence of vesicular stomatitis virus.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A novel nuclear structure containing the survival of motor neurons protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Purification of two isoforms of hnRNP-U and characterization of their nucleic acid binding activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299905

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

24 September 2018

1 reference

12 December 2020

A role for exon sequences and splice-site proximity in splice-site selection

1 reference

12 December 2020

Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

1 reference

12 December 2020

Separation of splicing factor SF3 into two components and purification of SF3a activity

1 reference

12 December 2020

Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9

1 reference

12 December 2020

Differential SMN2 expression associated with SMA severity

1 reference

12 December 2020

10.1016/J.MOLCEL.2012.01.009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22325991%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22325991%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22325991%20AND%20SRC:MED&resulttype=core&format=json