Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. (Q34530199)

2 August 2017

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. (English)

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2 August 2017

Alexander Hergovich

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2 August 2017

Joanna Lisztwan

2

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2 August 2017

Robert Barry

3

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2 August 2017

Pia Ballschmieter

4

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2 August 2017

Wilhelm Krek

5

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2 August 2017

1 January 2003

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2 August 2017

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2 August 2017

5

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2 August 2017

1

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2 August 2017

64-70

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https://scigraph.springernature.com/pub.10.1038/ncb899

2 August 2017

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cites work

Molecular basis of the VHL hereditary cancer syndrome

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

21 January 2018

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Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

21 January 2018

1 reference

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

21 January 2018

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

21 January 2018

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Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

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Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

21 January 2018

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Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

21 January 2018

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Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

21 January 2018

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Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

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Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect

21 January 2018

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Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

21 January 2018

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Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype

21 January 2018

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Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas

21 January 2018

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Software and database for the analysis of mutations in the VHL gene

21 January 2018

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Recurrent polytopic chromaffin paragangliomas in a 9-year-old boy resulting from a novel germline mutation in the von Hippel-Lindau gene

21 January 2018

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Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

21 January 2018

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Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

21 January 2018

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7 January 2021

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

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7 January 2021

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region

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7 January 2021

Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene

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7 January 2021

Identifiers

DOI

10.1038/NCB899

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Dimensions Publication ID

2 August 2017

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