Deacetylase enzymes: biological functions and the use of small-molecule inhibitors (Q34528043)

2 August 2017

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title

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors (English)

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2 August 2017

Christina M. Grozinger

series ordinal

1

object named as

Christina M Grozinger

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2 August 2017

2

Stuart L Schreiber

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2 August 2017

1 January 2002

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2 August 2017

Chemistry and Biology

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2 August 2017

9

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2 August 2017

1

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2 August 2017

3-16

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Acetylation: a regulatory modification to rival phosphorylation?

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The human histone deacetylase family

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Histone deacetylases, transcriptional control, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Cloning and characterization of a histone deacetylase, HDAC9

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Histone deacetylase activity is required for full transcriptional repression by mSin3A

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Crystallization and some properties of acetylpolyamine amidohydrolase from Mycoplana bullata

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The regulation of the butanediol cycle in Bacillus subtilis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Acetylpolyamine amidohydrolase from Mycoplana ramosa: gene cloning and characterization of the metal-substituted enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Histone deacetylases: transcriptional repression with SINers and NuRDs

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Sin meets NuRD and other tails of repression.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

CoREST is an integral component of the CoREST- human histone deacetylase complex

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The histone deacetylase-3 complex contains nuclear receptor corepressors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

1 reference

7 January 2021

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

CoREST: a functional corepressor required for regulation of neural-specific gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Pch2 links chromatin silencing to meiotic checkpoint control.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

An unusual form of transcriptional silencing in yeast ribosomal DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

RNA and Protein Metabolism in the Aging Brain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Chromatin profiling using targeted DNA adenine methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Molecular model for telomeric heterochromatin in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Nuclear compartments and gene regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Enzymatic activities of Sir2 and chromatin silencing

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

Crystal structure of a SIR2 homolog-NAD complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900092-3

7 January 2021

10.1016/S1074-5521(02)00092-3

Identifiers

DOI

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2 August 2017

1 reference

PubMed ID

11841934