Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis (Q34414642)

2 August 2017

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title

Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis (English)

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2 August 2017

Piek E

1

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PubMed ID

11665716

2 August 2017

Roberts AB

series ordinal

2

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2 August 2017

1 January 2001

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2 August 2017

54

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Advances in Cancer Research

inferred from page(s)

published in

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2 August 2017

83

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2 August 2017

1-54

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Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

2 August 2017

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7 January 2021

Alternative splicing within the TGF-beta type I receptor gene (ALK-5) generates two major functional isoforms in vascular smooth muscle cells

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7 January 2021

Genetic events and the role of TGF beta in epithelial tumour progression

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7 January 2021

Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.

1 reference

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7 January 2021

Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase plasminogen activator receptor

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7 January 2021

Kips off to Myc: implications for TGF beta signaling

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7 January 2021

Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

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7 January 2021

The plasminogen activation system in tumor growth, invasion, and metastasis

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7 January 2021

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.

1 reference

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7 January 2021

Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cells

1 reference

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7 January 2021

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1

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7 January 2021

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

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7 January 2021

Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

1 reference

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7 January 2021

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

1 reference

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7 January 2021

TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicity

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7 January 2021

Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome

1 reference

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7 January 2021

Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.

1 reference

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7 January 2021

Role of transforming growth factor beta in human disease

1 reference

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7 January 2021

Transforming growth factor beta in tissue fibrosis

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7 January 2021

Factors regulating the growth of metastatic cancer in bone

1 reference

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7 January 2021

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-β1 Modulated the Expression of α5β1 Integrin and Integrin-Mediated Signaling in Human Hepatocarcinoma Cells

1 reference

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7 January 2021

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

1 reference

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7 January 2021

The cellular homologue of the transforming gene of SKV avian retrovirus maps to human chromosome region 1q22----q24

1 reference

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7 January 2021

Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.

1 reference

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7 January 2021

Determinants of specificity in TGF-beta signal transduction.

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7 January 2021

1 reference

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7 January 2021

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice

1 reference

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7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

1 reference

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7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

1 reference

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7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

1 reference

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7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

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7 January 2021

Role of transforming growth factor-beta signaling in cancer

1 reference

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7 January 2021

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

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7 January 2021

Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts

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7 January 2021

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

1 reference

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7 January 2021

Oncogene-initiated aberrant signaling engenders the metastatic phenotype: synergistic transcription factor interactions are targets for cancer therapy.

1 reference

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7 January 2021

Smads: transcriptional activators of TGF-beta responses

1 reference

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7 January 2021

Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy

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7 January 2021

Genetic and epigenetic contributions to colorectal cancer

1 reference

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7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

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7 January 2021

Transforming growth factor-beta1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity.

1 reference

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7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

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7 January 2021

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

1 reference

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7 January 2021

Osteoblast conditioned media contain TGF-beta1 and modulate the migration of prostate tumor cells and their interactions with extracellular matrix components

1 reference

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7 January 2021

Osteoblast-derived TGF-β1 modulates matrix degrading protease expression and activity in prostate cancer cells

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7 January 2021

Blood vessel formation: what is its molecular basis?

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7 January 2021

Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors

1 reference

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7 January 2021

Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients

1 reference

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7 January 2021

Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII.

1 reference

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7 January 2021

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis

1 reference

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7 January 2021

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

1 reference

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7 January 2021

Molecular mechanisms of osteolytic bone metastases

1 reference

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7 January 2021

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta signaling in epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 reference

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7 January 2021

A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

An overview of epithelio-mesenchymal transformation

1 reference

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7 January 2021

1 reference

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7 January 2021

Activation of specific MEK-ERK cascade is necessary for TGFbeta signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes

1 reference

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7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Cyclosporine induces cancer progression by a cell-autonomous mechanism.

1 reference

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7 January 2021

Inactivation of the transforming growth factor beta type II receptor in human small cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

1 reference

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7 January 2021

Traps to catch unwary oncogenes

1 reference

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7 January 2021

Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Human cut-like repressor protein binds TGFbeta type II receptor gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Relationships between chromatin organization and DNA methylation in determining gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

1 reference

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7 January 2021

Antiproliferative effect of a vitamin D3 analog, EB1089, on HL-60 cells by the induction of TGF-beta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Establishment and characterization of a childhood pre-B acute lymphoblastic leukemia cell line, PER-278, with chromosome translocations t(1;19) and t(1;9).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta is a potent negative regulator of human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Growth Factors in the Regulation of Plasminogen-Plasmin System in Tumor Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Mechanism of E1A-induced transforming growth factor-beta (TGF-beta) resistance in mouse keratinocytes involves repression of TGF-beta type II receptor transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Mechanism of retinoid-induced activation of latent transforming growth factor-? in bovine endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Enhancement of vitronectin expression in human HepG2 hepatoma cells by transforming growth factor-beta 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Expression of Smad proteins in human colorectal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Regulation of immune responses by TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

CD105 antagonizes the inhibitory signaling of transforming growth factor beta1 on human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Defective angiogenesis in mice lacking endoglin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Two divergent signaling pathways for TGF-beta separated by a mutation of its type II receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Tumor suppressor activity of the TGF-beta pathway in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Interferon gamma and antisense transforming growth factor beta transgenes synergize to enhance the immunogenicity of a murine mammary carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Tumor-host interaction: analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor beta1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta/SMAD signaling and its involvement in tumor progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Role of Ras and Mapks in TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The prognostic significance of transforming growth factors in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Molecular control of vascular smooth muscle cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The distribution of secondary growths in cancer of the breast. 1889

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Potentiation of Smad transactivation by Jun proteins during a combined treatment with epidermal growth factor and transforming growth factor-beta in rat hepatocytes. role of phosphatidylinositol 3-kinase-induced AP-1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta 3 is required for secondary palate fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

1 reference

7 January 2021

Regulation of endothelial cell growth, architecture, and matrix synthesis by TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Differential expression of the TGF-beta isoforms in embryogenesis suggests specific roles in developing and adult tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Growth factors, apoptosis, and survival of mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

SMAD genes in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Genistein and curcumin block TGF-beta 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor beta: a model for avascularity in human cartilage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Immunoexpression of transforming growth factor beta in desmoplastic ameloblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Gastro-intestinal tumorigenesis in Smad4 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-beta stimulates interleukin-11 transcription via complex activating protein-1-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Transforming growth factor-β enhances adhesion of melanoma cells to the endotheliumin vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Zebrafish nma is involved in TGFbeta family signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

The role of thrombospondin-1 in tumor progression and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Multiple modes of repression by the Smad transcriptional corepressor TGIF

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Increased transforming growth factor beta1 plasma level in patients with renal cell carcinoma: a tumor-specific marker?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Regulation of Smad signaling by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Suppression of TGF-beta1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Relationship of levels and kinetics of H-ras expression to transformed phenotype and loss of TGF-beta 1-mediated growth regulation in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

1 reference

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

Signaling angiogenesis via p42/p44 MAP kinase cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2801%2983001-3

7 January 2021

10.1016/S0065-230X(01)83001-3

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11665716