Gamma-secretase inhibitors and Alzheimer's disease (Q34161046)

31 July 2017

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title

Gamma-secretase inhibitors and Alzheimer's disease (English)

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31 July 2017

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Susan B Roberts

1

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PubMed ID

12453675

31 July 2017

language of work or name

English

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publication date

1 December 2002

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Advanced Drug Delivery Reviews

31 July 2017

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31 July 2017

54

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31 July 2017

12

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31 July 2017

1579-1588

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New frontiers in Alzheimer's disease genetics

31 July 2017

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilins as therapeutic targets for the treatment of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Secretase targets for Alzheimer's disease: identification and therapeutic potential

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

The Role of presenilins in gamma-secretase activity

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Secretases as therapeutic targets for the treatment of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Implication of APP secretases in notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Gamma -secretase inhibitors repress thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

gamma-Secretase inhibitors as molecular probes of presenilin function

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900155-2

7 January 2021

10.1016/S0169-409X(02)00155-2

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12453675