Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities (Q34129826)

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English	Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities (English)

1 reference

Europe PubMed Central

31 July 2017

author name string

Takesh Ikeuchi

1

1 reference

Europe PubMed Central

31 July 2017

Sangram S Sisodia

2

1 reference

Europe PubMed Central

31 July 2017

publication date

1 January 2002

1 reference

Europe PubMed Central

31 July 2017

NeuroMolecular Medicine

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Europe PubMed Central

31 July 2017

1

1 reference

Europe PubMed Central

31 July 2017

1

1 reference

Europe PubMed Central

31 July 2017

43-54

1 reference

Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1385/nmm:1:1:43

0 references

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A detergent-free method for purifying caveolae membrane from tissue culture cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear access and action of notch in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling: cell fate control and signal integration in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free assays for gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/NMM:1:1:43

1 reference

Europe PubMed Central

31 July 2017

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release_sfjz2qto35cxxkkthffvdoqo5q

1 reference

https://api.fatcat.wiki/v0/release/sfjz2qto35cxxkkthffvdoqo5q

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

31 July 2017

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