WNK1 activates SGK1 to regulate the epithelial sodium channel. (Q33900653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006511%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

WNK1 activates SGK1 to regulate the epithelial sodium channel (English)

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30 December 2019

10

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30 December 2019

author name string

Bing-e Xu

1

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30 December 2019

Steve Stippec

2

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30 December 2019

Po-Yin Chu

3

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30 December 2019

Ahmed Lazrak

4

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30 December 2019

Xin-Ji Li

5

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30 December 2019

Byung-Hoon Lee

6

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30 December 2019

Jessie M English

7

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30 December 2019

Bernardo Ortega

8

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30 December 2019

Chou-Long Huang

9

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30 December 2019

language of work or name

English

0 references

publication date

8 July 2005

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

30 December 2019

published in

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30 December 2019

volume

102

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30 December 2019

page(s)

10315-10320

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30 December 2019

issue

29

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Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

30 December 2019

cites work

1 reference

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The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport

5 July 2018

1 reference

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WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

5 July 2018

1 reference

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A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit

5 July 2018

1 reference

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Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

5 July 2018

1 reference

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Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

5 July 2018

1 reference

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WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

5 July 2018

1 reference

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WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

5 July 2018

1 reference

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Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

5 July 2018

1 reference

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Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium.

5 July 2018

1 reference

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Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

5 July 2018

1 reference

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WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH.

5 July 2018

1 reference

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Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

5 July 2018

1 reference

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The role of Nedd4/Nedd4-like dependant ubiquitylation in epithelial transport processes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.

5 July 2018

1 reference

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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Impaired renal Na(+) retention in the sgk1-knockout mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

5 July 2018

1 reference

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Genome-wide detection of tissue-specific alternative splicing in the human transcriptome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Hypotonic induction of SGK1 and Na+ transport in A6 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Monogenic forms of human hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel

5 July 2018

1 reference

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WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

5 July 2018

1 reference

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Human hypertension caused by mutations in WNK kinases

5 July 2018

1 reference

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BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Cloning and functional expression of the mouse epithelial sodium channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Epithelial sodium channel regulated by aldosterone-induced protein sgk.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Gene identification using the yeast two-hybrid system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Genetic determinants of human hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Blood pressure control--special role of the kidneys and body fluids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1177404

Familial hyperkalemic hypertension: phenotypic analysis in a large family with the WNK1 deletion mutation

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16006511

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The syndrome of hypertension and hyperkalemia with normal glomerular filtration rate: Gordon's syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16006511

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16006511

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0504422102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006511%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006511%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference