Galectin 3 (Q3094567)

http://www.ebi.ac.uk/interpro/protein/P17931

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17931

Galectin, carbohydrate recognition domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

10 references

9 May 2019

Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Modulation of CD6 function through interaction with Galectin-1 and -3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Molecular cloning of a human macrophage lectin specific for galactose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

IPI

chemoattractant activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

8 April 2019

Molecular cloning of a human macrophage lectin specific for galactose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

3 references

9 May 2019

Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans

oligosaccharide binding

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

1 reference

9 May 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

protein phosphatase inhibitor activity

HDA

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

protein phosphatase binding

IC

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

immunological synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

mitochondrial inner membrane

1 reference

9 May 2019

Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

extracellular exosome

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

8 April 2019

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

2 references

secretory granule membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

ficolin-1-rich granule membrane

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

17 October 2017

Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

collagen-containing extracellular matrix

HDA

5 references

9 May 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

HDA

extracellular exosome

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

3 references

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of endocytosis

IBA

biological process

1 reference

8 April 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

regulation of T cell proliferation

1 reference

9 May 2019

Expression of galectin-3 modulates T-cell growth and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of immunological synapse formation

IMP

1 reference

9 May 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

epithelial cell differentiation

ISS

1 reference

9 May 2019

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

8 April 2019

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

immune system process

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

eosinophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of extrinsic apoptotic signaling pathway

1 reference

8 April 2019

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

positive regulation of mononuclear cell migration

1 reference

9 May 2019

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of T cell receptor signaling pathway

1 reference

9 May 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

mononuclear cell migration

ISS

1 reference

9 May 2019

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

positive regulation of calcium ion import

1 reference

8 April 2019

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

macrophage chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

regulation of T cell apoptotic process

1 reference

9 May 2019

Expression of galectin-3 modulates T-cell growth and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

positive regulation of dendritic cell differentiation

1 reference

9 May 2019

Galectin-9 induces maturation of human monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

9 May 2019

Expression of galectin-3 modulates T-cell growth and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

IMP

1 reference

9 May 2019

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

1 reference

8 April 2019

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

innate immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

neutrophil degranulation

1 reference

9 May 2019

antimicrobial humoral immune response mediated by antimicrobial peptide

TAS

1 reference

17 October 2017

Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17931&geneProductId=UniProtKB:P17931

regulation of myeloid cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

positive regulation of protein homodimerization activity

TAS

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

positive regulation of protein localization to plasma membrane

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

negative regulation of protein tyrosine phosphatase activity

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17931

Galectin, carbohydrate recognition domain

IC

Gene Atlas image

PBB GE LGALS3 208949 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17931

Identifiers

MeSH descriptor ID

C428445

subject named as

LGALS3 protein, human

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016