Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats. (Q30497679)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20978127%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats (English)

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14 January 2020

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3

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14 January 2020

Kohei Fujikura

5

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14 January 2020

author name string

Yasunori Yamamoto

1

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14 January 2020

Sumiko Mochida

2

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14 January 2020

Katsuhisa Kawai

4

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14 January 2020

Takao Kurooka

6

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14 January 2020

Kenji Iwasaki

7

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14 January 2020

Toshiaki Sakisaka

8

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14 January 2020

language of work or name

English

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publication date

26 October 2010

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Journal of Biological Chemistry

14 January 2020

published in

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14 January 2020

volume

285

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14 January 2020

issue

52

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14 January 2020

page(s)

40943-40955

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The tail domain of tomosyn controls membrane fusion through tomosyn displacement by VAMP2.

14 January 2020

cites work

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Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

20 June 2018

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Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming

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Reciprocal intramolecular interactions of tomosyn control its inhibitory activity on SNARE complex formation

20 June 2018

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20 June 2018

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Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

20 June 2018

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How does synaptotagmin trigger neurotransmitter release?

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Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism

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Molecular anatomy of a trafficking organelle

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The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release

20 June 2018

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A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

20 June 2018

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SNAREs--engines for membrane fusion

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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans

20 June 2018

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PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter

20 June 2018

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20 June 2018

Synaptic vesicle pools

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Structural basis for the inhibitory role of tomosyn in exocytosis

20 June 2018

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The synaptic vesicle cycle

20 June 2018

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Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner

20 June 2018

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Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels

20 June 2018

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Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

20 June 2018

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Estimation of quantal parameters at the calyx of Held synapse

20 June 2018

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Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

20 June 2018

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Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion

20 June 2018

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Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling.

20 June 2018

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How does calcium trigger neurotransmitter release?

20 June 2018

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Synaptotagmin I functions as a calcium regulator of release probability

20 June 2018

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The synaptic vesicle cycle revisited

20 June 2018

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Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X

20 June 2018

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Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

20 June 2018

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

20 June 2018

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Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process

20 June 2018

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SNAREpins: minimal machinery for membrane fusion

20 June 2018

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Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

20 June 2018

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Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

20 June 2018

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Evidence for cholinergic synapses between dissociated rat sympathetic neurons in cell culture

20 June 2018

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Morphological and cytochemical studies of synapses formed in culture between isolated rat superior cervical ganglion neurons.

20 June 2018

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Localization and subcellular distribution of cellular ras gene products in rat brain

20 June 2018

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Postnatal rat sympathetic neurons in culture. II. Synaptic transmission by postnatal neurons

20 June 2018

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20 June 2018

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Synaptic transmission between rat superior cervical ganglion neurons in dissociated cell cultures

20 June 2018

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Synaptic transmission between rat spinal cord explants and dissociated superior cervical ganglion neurons in tissue culture

20 June 2018

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Synaptic vesicle cytochemistry changes when cultured sympathetic neurones develop cholinergic interactions

20 June 2018

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Morphological correlates of functionally defined synaptic vesicle populations

20 June 2018

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The structural organization of the readily releasable pool of synaptic vesicles

21 January 2018

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Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

21 January 2018

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Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release.

21 January 2018

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Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.

21 January 2018

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Multiple functional domains are involved in tomosyn regulation of exocytosis.

21 January 2018

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A cholinergic model synapse to elucidate protein function at presynaptic terminals.

21 January 2018

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The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

21 January 2018

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Two modes of vesicle recycling in the rat calyx of Held.

21 January 2018

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Analysis of the mechanism for acetylcholine release at the synapse formed between rat sympathetic neurons in culture

26 November 2018

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12 December 2020

Role of myosin in neurotransmitter release: functional studies at synapses formed in culture

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12 December 2020

Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels

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12 December 2020

Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.156893

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20978127%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20978127%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference