Raf oncogene Dmel_CG2845 (Q29812464)

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Protein found in Drosophila melanogaster

pole hole
Raf-PE
Raf-PA
Raf oncogene
polehole
raf-like-oncogene-1
CG2845-PA
l(1)pole hole
CG2845 gene product from transcript CG2845-RE
pole-hole
Raf
CG2845-PE

Language	Label	Description	Also known as
English	Raf oncogene Dmel_CG2845	Protein found in Drosophila melanogaster	pole hole Raf-PE Raf-PA Raf oncogene polehole raf-like-oncogene-1 CG2845-PA l(1)pole hole CG2845 gene product from transcript CG2845-RE pole-hole Raf CG2845-PE

Statements

1 reference

25 May 2022

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Raf-like Ras-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

protein kinase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

MAP kinase kinase kinase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

protein binding

determination method

3 references

1 January 2018

Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

1 January 2018

The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

1 January 2018

CNK, a RAF-binding multidomain protein required for RAS signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

kinase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

transferase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

mitogen-activated protein kinase kinase binding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

metal ion binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

biological process

determination method

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

instar larval development

determination method

1 reference

1 January 2018

Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

protein phosphorylation

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

epidermal growth factor receptor signaling pathway

determination method

1 reference

1 January 2018

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

spermatogenesis

determination method

1 reference

1 January 2018

Somatic control over the germline stem cell lineage during Drosophila spermatogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

border follicle cell migration

determination method

1 reference

1 January 2018

Two distinct modes of guidance signalling during collective migration of border cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

determination method

1 reference

1 January 2018

Coactivation of STAT and Ras Is Required for Germ Cell Proliferation and Invasive Migration in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

primary branching, open tracheal system

determination method

1 reference

1 January 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

wing disc morphogenesis

determination method

1 reference

1 January 2018

Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

1 January 2018

Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

determination method

1 reference

1 January 2018

The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

circadian rhythm

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

dorsal/ventral axis specification, ovarian follicular epithelium

determination method

1 reference

1 January 2018

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

positive regulation of cell population proliferation

determination method

1 reference

1 January 2018

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

torso signaling pathway

determination method

1 reference

1 January 2018

Characterization of maternal and zygotic D-raf proteins: dominant negative effects on Torso signal transduction.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

imaginal disc-derived wing vein morphogenesis

determination method

1 reference

1 January 2018

The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

cellular response to starvation

determination method

1 reference

1 January 2018

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

negative regulation of macroautophagy

determination method

1 reference

1 January 2018

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

phosphorylation

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

determination method

1 reference

1 January 2018

Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

regulation of cellular pH

determination method

1 reference

1 January 2018

Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

wing and notum subfield formation

determination method

1 reference

1 January 2018

DER signaling restricts the boundaries of the wing field during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

intracellular signal transduction

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

regulation of multicellular organism growth

determination method

1 reference

1 January 2018

Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

hemocyte differentiation

determination method

photoreceptor cell development

determination method

1 reference

1 January 2018

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

positive regulation of photoreceptor cell differentiation

determination method

1 reference

1 January 2018

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

positive regulation of Ras protein signal transduction

determination method

1 reference

1 January 2018

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

protein autophosphorylation

determination method

1 reference

1 January 2018

Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

regulation of cell cycle

determination method

1 reference

1 January 2018

A protein network-guided screen for cell cycle regulators in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

1 January 2018

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

negative regulation of apoptotic signaling pathway

determination method

1 reference

1 January 2018

Ras promotes cell survival in Drosophila by downregulating hid expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

determination method

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

Raf-like Ras-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11346

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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