Mechanisms linking obesity to insulin resistance and type 2 diabetes (Q29614887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17167471%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

review article

1 reference

title

Mechanisms linking obesity to insulin resistance and type 2 diabetes (English)

2 references

PubMed

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17167471

30 April 2017

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23 December 2019

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1

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23 December 2019

author name string

Rebecca L Hull

series ordinal

2

1 reference

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23 December 2019

Kristina M Utzschneider

series ordinal

3

1 reference

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23 December 2019

language of work or name

1 reference

30 April 2017

publication date

1 December 2006

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23 December 2019

2 references

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30 April 2017

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23 December 2019

volume

444

2 references

PubMed

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30 April 2017

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23 December 2019

issue

7121

2 references

PubMed

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30 April 2017

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23 December 2019

page(s)

840-846

1 reference

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Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.

23 December 2019

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Plasma insulin responses to glucose and tolbutamide of normal weight and obese diabetic and nondiabetic subjects.

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Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects

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Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

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Insulin resistance during puberty: results from clamp studies in 357 children.

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Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes.

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Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin

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Exercise, glucose transport, and insulin sensitivity

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Inflammation, stress, and diabetes

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Adipose tissue: from lipid storage compartment to endocrine organ

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Inflammation and insulin resistance

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

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Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

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7 January 2021

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

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7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

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7 January 2021

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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7 January 2021

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

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7 January 2021

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

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7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

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7 January 2021

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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7 January 2021

Cellular mechanisms of insulin resistance

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7 January 2021

Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM.

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7 January 2021

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.

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7 January 2021

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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7 January 2021

Preventing diabetes--applying pathophysiological and epidemiological evidence

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7 January 2021

Analysis of an expression profile of genes in the human adipose tissue

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7 January 2021

Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone

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7 January 2021

The perils of portliness: causes and consequences of visceral adiposity

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7 January 2021

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

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7 January 2021

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells

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7 January 2021

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

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7 January 2021

Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance

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7 January 2021

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion

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7 January 2021

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

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7 January 2021

Why visceral fat is bad: mechanisms of the metabolic syndrome

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7 January 2021

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

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7 January 2021

The biology of incretin hormones

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7 January 2021

The role of postprandial releases of insulin and incretin hormones in meal-induced satiety--effect of obesity and weight reduction

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7 January 2021

Acute Hyperinsulinemia and Its Reversal by Vagotomy after Lesions of the Ventromedial Hypothalamus in Anesthetized Rats*

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7 January 2021

Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion

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7 January 2021

Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation

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7 January 2021

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

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7 January 2021

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

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7 January 2021

Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression

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7 January 2021

Type 2 diabetes-a matter of beta-cell life and death?

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7 January 2021

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

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7 January 2021

Ventromedial hypothalamic lesion-induced vagal hyperactivity stimulates rat pancreatic cell proliferation.

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7 January 2021

The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus.

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7 January 2021

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

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7 January 2021

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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7 January 2021

Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses

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7 January 2021

Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus

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7 January 2021

Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus

1 reference

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7 January 2021

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance

1 reference

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7 January 2021

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

1 reference

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7 January 2021

Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes

1 reference

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7 January 2021

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1 reference

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7 January 2021

The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study

1 reference

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7 January 2021

https://api.crossref.org/works/10.1038%2FNATURE05482

1 reference

7 January 2021

Genetics of Type 2 diabetes.

1 reference

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7 January 2021

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

1 reference

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7 January 2021

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

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7 January 2021

Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men.

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7 January 2021

Central nervous system control of food intake

1 reference

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7 January 2021

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

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7 January 2021

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17167471

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

28978

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23 December 2019

1034631385

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28978

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17167471

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

28978

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17167471%20AND%20SRC:MED&resulttype=core&format=json