A simple method for quantifying functional selectivity and agonist bias (Q28728741)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22860188%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

A simple method for quantifying functional selectivity and agonist bias (English)

1 reference

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9 February 2020

0 references

1 reference

4

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9 February 2020

author name string

Terry Kenakin

1

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9 February 2020

Christian Watson

2

1 reference

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9 February 2020

Vanessa Muniz-Medina

3

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9 February 2020

Steven Novick

5

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9 February 2020

language of work or name

English

0 references

publication date

20 December 2011

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ACS Chemical Neuroscience

9 February 2020

published in

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9 February 2020

volume

3

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9 February 2020

issue

3

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9 February 2020

page(s)

193-203

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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

9 February 2020

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

17 March 2017

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Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias

3 June 2018

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'7TM receptor allostery: putting numbers to shapeshifting proteins

3 June 2018

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Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity

3 June 2018

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Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors

3 June 2018

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Beta-arrestin-biased ligands at seven-transmembrane receptors

3 June 2018

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GPCR functional selectivity has therapeutic impact

3 June 2018

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

3 June 2018

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Implementation of BacMam virus gene delivery technology in a drug discovery setting

3 June 2018

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Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

3 June 2018

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Regulation of alpha2AR trafficking and signaling by interacting proteins

3 June 2018

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Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

3 June 2018

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G-Protein-coupled receptor-protein interactions: basis for new concepts on receptor structure and function

3 June 2018

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Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.

3 June 2018

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Multiple signaling states of G-protein-coupled receptors

3 June 2018

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STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE

3 June 2018

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The ethyleneiminium ion as the active species in 2-haloalkylamine compounds

3 June 2018

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G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

3 June 2018

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Drug efficacy at G protein-coupled receptors

3 June 2018

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Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins

3 June 2018

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Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

3 June 2018

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Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles

3 June 2018

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Operational models of pharmacological agonism.

3 June 2018

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An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation

3 June 2018

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Multiple mechanisms of serotonergic signal transduction

3 June 2018

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3 June 2018

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Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes

27 November 2018

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Analysis of allosterism in functional assays

27 November 2018

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Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22860188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacological basis for functional selectivity of partial muscarinic receptor agonists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22860188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CN200111M

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22860188%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

2 references

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9 February 2020

2 references

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