Loss of locus coeruleus neurons and reduced startle in parkin null mice (Q28593443)

23 June 2017

Loss of locus coeruleus neurons and reduced startle in parkin null mice (English)

1 reference

Parkin RBR E3 ubiquitin protein ligase

23 June 2017

1 reference

GOA release 2020-03-11

8

Ted M Dawson

1 reference

23 June 2017

Rainer Von Coelln

1

1 reference

23 June 2017

Bobby Thomas

2

1 reference

23 June 2017

Kah Leong Lim

4

1 reference

23 June 2017

Masayuki Sasaki

5

1 reference

23 June 2017

Joseph M Savitt

3

1 reference

23 June 2017

Ellen J Hess

6

1 reference

23 June 2017

Valina L Dawson

7

1 reference

23 June 2017

language of work or name

English

0 references

publication date

12 July 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

23 June 2017

1 reference

23 June 2017

101

1 reference

23 June 2017

29

1 reference

23 June 2017

10744-10749

1 reference

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

23 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Staging of brain pathology related to sporadic Parkinson's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Mechanisms underlying ubiquitination

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Alpha-synuclein in Lewy bodies

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Association between early-onset Parkinson's disease and mutations in the parkin gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Molecular Pathways of Neurodegeneration in Parkinson's Disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Parkinson's disease. First of two parts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Are ubiquitination pathways central to Parkinson's disease?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Complex relationship between Parkin mutations and Parkinson disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Differential expression of the parkin gene in the human brain and peripheral leukocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

New stereological methods for counting neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Norepinephrine effects on spinal motoneurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Efferent projections of different subpopulations of central noradrenaline neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Identification and characterization of the human parkin gene promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Central noradrenergic involvement in yohimbine excitation of acoustic startle: effects of DSP4 and 6-OHDA.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Noradrenaline neuron innervation of the neocortex in the rat

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490005

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Role of dopamine in prepulse inhibition of acoustic startle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Effects of 6-hydroxydopamine lesions of locus coeruleus on startle in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Targeted disruption of the neuronal nitric oxide synthase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Deletion of exon 6 of the neuronal nitric oxide synthase gene in mice results in hypogonadism and infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401297101

Genetics of Parkinson's disease

21 January 2018

1 reference

12 December 2020

An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene.

1 reference

12 December 2020

The genetics of Parkinson's disease

1 reference

12 December 2020

Spinal modulation of the acoustic startle response: the role of norepinephrine, serotonin and dopamine

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0401297101

1 reference

23 June 2017

0 references

0 references

1 reference