Essential role of limiting telomeres in the pathogenesis of Werner syndrome (Q28588253)

GOA release 2020-03-11

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David Lombard

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Leonard P. Guarente

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object named as

Leonard Guarente

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31 January 2017

Sandy Chang

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31 January 2017

Asha S. Multani

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31 January 2017

Noelia G. Cabrera

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31 January 2017

Maria L. Naylor

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31 January 2017

Purnima Laud

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31 January 2017

Sen Pathak

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31 January 2017

Ronald A. DePinho

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

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31 January 2017

language of work or name

English

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publication date

1 August 2004

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31 January 2017

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31 January 2017

36

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877–882

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31 January 2017

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31 January 2017

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Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

21 April 2017

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SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

21 April 2017

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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

21 April 2017

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

21 April 2017

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 April 2017

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RecQ helicases: caretakers of the genome

21 April 2017

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A DNA damage checkpoint response in telomere-initiated senescence

21 April 2017

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DNA damage foci at dysfunctional telomeres

21 April 2017

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Lessons from human progeroid syndromes

21 April 2017

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7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

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7 January 2021

Positional cloning of the Werner's syndrome gene

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7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

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7 January 2021

Replication focus-forming activity 1 and the Werner syndrome gene product

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7 January 2021

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

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7 January 2021

Spectral karyotyping of Werner syndrome fibroblast cultures.

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7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

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7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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7 January 2021

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

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7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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7 January 2021

Expression of the BLM gene in human haematopoietic cells

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7 January 2021

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

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7 January 2021