A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint (Q28472643)

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17 January 2020

title

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint (English)

1 reference

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17 January 2020

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1 reference

7

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17 January 2020

T.A. Lewis

12

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17 January 2020

Stephen J Smerdon

14

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17 January 2020

3

Rune Linding

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17 January 2020

Marcel A T M van Vugt

1

object named as

Marcel A T M van Vugt

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17 January 2020

author name string

Alexandra K Gardino

2

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17 January 2020

Gerard J Ostheimer

4

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17 January 2020

H Christian Reinhardt

5

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17 January 2020

Shao-En Ong

6

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17 January 2020

Hua Miao

8

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17 January 2020

Susan M Keezer

9

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17 January 2020

Jeijin Li

10

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17 January 2020

Steven A Carr

13

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17 January 2020

Thijn R Brummelkamp

15

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17 January 2020

Michael B Yaffe

16

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17 January 2020

Tony Pawson

11

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17 January 2020

language of work or name

English

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publication date

26 January 2010

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17 January 2020

1 reference

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17 January 2020

volume

8

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17 January 2020

page(s)

e1000287

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17 January 2020

issue

1

1 reference

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Creative Commons Attribution 4.0 International

17 January 2020

copyright license

start time

26 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

19 March 2017

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Cell cycle control by the CDC25 phosphatases

19 March 2017

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19 March 2017

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

7 April 2017

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

7 April 2017

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PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation

7 April 2017

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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

7 April 2017

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Brca1 controls homology-directed DNA repair

7 April 2017

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Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

7 April 2017

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

7 April 2017

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Linear Motif Atlas for Phosphorylation-Dependent Signaling

7 April 2017

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Systematic Discovery of In Vivo Phosphorylation Networks

9 May 2017

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

9 May 2017

1 reference

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

9 May 2017

1 reference

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NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

29 September 2017

1 reference

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53BP1 facilitates long-range DNA end-joining during V(D)J recombination

29 September 2017

1 reference

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Aurora kinases as anticancer drug targets

29 September 2017

1 reference

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Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

29 September 2017

1 reference

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DNA damage checkpoints: from initiation to recovery or adaptation

29 September 2017

1 reference

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

29 September 2017

1 reference

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Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

The tandem BRCT domain of 53BP1 is not required for its repair function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

29 September 2017

1 reference

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Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks

29 September 2017

1 reference

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

29 September 2017

1 reference

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An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

29 September 2017

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Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

29 September 2017

1 reference

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

29 September 2017

1 reference

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Checkpoint adaptation and recovery: back with Polo after the break

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Mutations in CHEK2 associated with prostate cancer risk

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

53BP1, a mediator of the DNA damage checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Chk2 activation and phosphorylation-dependent oligomerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Monoclonal antibodies to mitotic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Posttranscriptional derepression of GADD45alpha by genotoxic stress.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Phospho.ELM: a database of phosphorylation sites--update 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Targeting polo-like kinase 1 for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000287

Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811157

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

27 November 2018

1 reference

12 December 2020

CDC5 and CKII control adaptation to the yeast DNA damage checkpoint

1 reference

12 December 2020

MEC1-dependent phosphorylation of Rad9p in response to DNA damage

1 reference

12 December 2020

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

1 reference

12 December 2020

A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis

1 reference

12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.1000287

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20126263%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20126263%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

2 references