Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation (Q28285317)

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J Kuang

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L Zhong

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W L Kuo

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A Sahin

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B R Brinkley

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S Sen

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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language of work or name

English

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publication date

October 1998

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published in

Nature Genetics

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volume

20

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issue

2

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page(s)

189-93

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cites work

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization

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Genetic screening of head-neck carcinomas using comparative genomic hybridization (CGH)

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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

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Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation

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Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1

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ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis.

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A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators

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CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner

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Phosphoproteins are components of mitotic microtubule organizing centers

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Taxol-induced microtubule asters in mitotic extracts of Xenopus eggs: requirement for phosphorylated factors and cytoplasmic dynein

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Cell-cycle-regulated localization of tyrosine and threonine phosphoepitopes at the kinetochores of mitotic chromosomes.

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Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase

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A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.

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Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

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Abnormal centrosome amplification in the absence of p53.

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Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

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Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity

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Mutations of mitotic checkpoint genes in human cancers

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A checkpoint on the road to cancer

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Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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