Human Smad3 and Smad4 are sequence-specific transcription activators (Q28276193)

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object named as

K W Kinzler

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author name string

L Zawel

1

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J L Dai

2

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P Buckhaults

3

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S Zhou

4

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S E Kern

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

7

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language of work or name

English

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publication date

March 1998

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published in

Molecular Cell

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volume

1

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page(s)

611-7

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issue

4

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cites work

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A transcriptional partner for MAD proteins in TGF-beta signalling

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Smad4 and FAST-1 in the assembly of activin-responsive factor

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

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DPC4 gene mutation in colitis associated neoplasia

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

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Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins

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The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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A human Mad protein acting as a BMP-regulated transcriptional activator

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Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

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Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway

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Differential effect of Nonidet P40 on DNA binding of transcription factors.

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Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein

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Mad-related genes in the human

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Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

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A structural basis for mutational inactivation of the tumour suppressor Smad4

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TGF beta signals through a heteromeric protein kinase receptor complex

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Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

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