Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing (Q28251171)

Richard Allmendinger

3

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Barry W McColl

Barry W McColl

2

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Gloria López-Castejón

Gloria López-Castejón

5

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David Brough

David Brough

9

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Pedro Mendes

Pedro Mendes

8

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Douglas Kell

Douglas B Kell

10

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Jürgen Pahle

Jürgen Pahle

4

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Nancy Rothwell

6

Nancy J Rothwell

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Joshua Knowles

Joshua Knowles

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

7

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language of work or name

English

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publication date

23 October 2011

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published in

Nature Chemical Biology

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volume

7

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issue

12

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page(s)

902-8

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Network pharmacology: the next paradigm in drug discovery

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Physiological control of metabolic flux: the requirement for multisite modulation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Nonresolving inflammation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Global mapping of pharmacological space

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Biologic basis for interleukin-1 in disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Systems approaches and algorithms for discovery of combinatorial therapies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Cheminformatics approaches to analyze diversity in compound screening libraries.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Protein dynamics in drug combinations: a linear superposition of individual-drug responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Targeting the cancer kinome through polypharmacology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

"Go upstream, young man": lessons learned from the p38 saga

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Synergistic drug combinations tend to improve therapeutically relevant selectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

The value of drug repositioning in the current pharmaceutical market

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Combination chemical genetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

LPS/TLR4 signal transduction pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Multiobjective optimization in bioinformatics and computational biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Multi-target therapeutics: when the whole is greater than the sum of the parts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

A comprehensive map of the toll-like receptor signaling network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

The search for synergy: a critical review from a response surface perspective.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223407

Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

Systems biology and combination therapy in the quest for clinical efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.689

COPD and co-morbidities, with special emphasis on cardiovascular conditions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22020553

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanisms of drug combinations: interaction and network perspectives

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22020553

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.689

1 reference

4154589

4154589

1 reference

1 reference

1 reference