Cancer susceptibility and the functions of BRCA1 and BRCA2 (Q28217784)

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

Europe PubMed Central

title

Cancer susceptibility and the functions of BRCA1 and BRCA2 (English)

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author name string

Ashok R Venkitaraman

series ordinal

1

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language of work or name

English

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publication date

25 January 2002

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published in

Cell

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volume

108

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issue

2

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page(s)

171-82

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cites work

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With the ends in sight: images from the BRCA1 tumor suppressor.

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BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

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7 January 2021

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

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Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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7 January 2021

The importance of repairing stalled replication forks

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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

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7 January 2021

The human decatenation checkpoint.

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7 January 2021

How many more breast cancer predisposition genes are there?

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7 January 2021

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

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7 January 2021

BRCA2 associates with acetyltransferase activity when bound to P/CAF

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7 January 2021

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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7 January 2021

BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications

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7 January 2021

BRCA1 required for transcription-coupled repair of oxidative DNA damage

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7 January 2021

Gatekeepers of recombination

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

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7 January 2021

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

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7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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7 January 2021

DNA double strand break repair in mammalian cells

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

Cancer-susceptibility genes. Gatekeepers and caretakers

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7 January 2021

Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50

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7 January 2021

The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression

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7 January 2021

Break-induced replication: a review and an example in budding yeast

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Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations

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7 January 2021

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

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7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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7 January 2021

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

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7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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7 January 2021

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

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7 January 2021

DNA double-strand breaks caused by replication arrest

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7 January 2021

Brca1 controls homology-directed DNA repair

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7 January 2021

BRCA2 is required for homology-directed repair of chromosomal breaks

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7 January 2021

Breast cancer genetics: what we know and what we need

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7 January 2021

Mitotic kinases as regulators of cell division and its checkpoints

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7 January 2021

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

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7 January 2021

Involvement of Brca2 in DNA repair

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7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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7 January 2021

Direct DNA binding by Brca1

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7 January 2021

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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7 January 2021

In search of the tumour-suppressor functions of BRCA1 and BRCA2

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7 January 2021

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

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7 January 2021

RuvAB acts at arrested replication forks

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7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

1 reference

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7 January 2021

Brca2 is required for embryonic cellular proliferation in the mouse

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7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

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7 January 2021

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

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7 January 2021

Chromosomal stability and the DNA double-stranded break connection

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7 January 2021

The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?

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7 January 2021

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

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7 January 2021

Effect of DNA damage on a BRCA1 complex

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7 January 2021

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

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7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

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7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

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7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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7 January 2021

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

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7 January 2021

BRCA1 interacts with components of the histone deacetylase complex

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7 January 2021

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations

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7 January 2021

Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1

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7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

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7 January 2021

Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism

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7 January 2021

10.1016/S0092-8674(02)00615-3

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

359746

359746

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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