MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation (Q28204918)

1

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Shelya X Zeng

2

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Mu-Shui Dai

3

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Xiang-Jiao Yang

4

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Hua Lu

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

23 August 2002

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published in

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volume

277

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issue

34

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page(s)

30838-43

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cites work

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Deacetylation of p53 modulates its effect on cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Histone deacetylases specifically down-regulate p53-dependent gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Mdm2 association with p53 targets its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

pEXPRESS: A family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Kinetics of p53 binding to promoter sites in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

Role for p300 in stabilization of p53 in the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204078200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204078200

1 reference

Consolidated OpenCitations Corpus – April 2017

4623564

4623564

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference