The engagement of Sec61p in the ER dislocation process (Q27932365)

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

GOA release 2020-03-11

author

Randy Schekman

series ordinal

2

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author name string

M Zhou

series ordinal

1

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language of work or name

English

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publication date

December 1999

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1 reference

1 December 2016

4

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issue

6

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page(s)

925-34

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cites work

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7 January 2021

Role of Cue1p in ubiquitination and degradation at the ER surface

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Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

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7 January 2021

Glycosylation and structure of the yeast MF alpha 1 alpha-factor precursor is important for efficient transport through the secretory pathway

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7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus

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7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

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7 January 2021

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum

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7 January 2021

Protein folding in the cell

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7 January 2021

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

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7 January 2021

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

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7 January 2021

Quality control in the secretory pathway

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7 January 2021

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

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7 January 2021

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

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7 January 2021

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

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7 January 2021

The signal recognition particle in S. cerevisiae

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7 January 2021

Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum

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7 January 2021

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

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7 January 2021

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor

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7 January 2021

Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

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7 January 2021

Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII

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7 January 2021

A proteolytic pathway that recognizes ubiquitin as a degradation signal

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7 January 2021

Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response

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7 January 2021

ER quality control: the cytoplasmic connection

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7 January 2021

Folding of Secretory and Membrane Proteins

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7 January 2021

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

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7 January 2021

Go outside and see the proteasome. Protein degradation

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7 January 2021

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae

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7 January 2021

Protein translocation: tunnel vision

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7 January 2021

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

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7 January 2021

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

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7 January 2021

Inducible membranes in yeast: relation to the unfolded-protein-response pathway

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7 January 2021

Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

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7 January 2021

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast

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7 January 2021

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

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7 January 2021

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane

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7 January 2021

Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

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7 January 2021

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

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7 January 2021

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Sec61p and BiP directly facilitate polypeptide translocation into the ER.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Genetic analysis of protein export in Escherichia coli

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7 January 2021

Polypeptide translocation: a pretty picture is worth a thousand words

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7 January 2021

Getting started with yeast

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7 January 2021

Mechanisms of translocation of proteins across membranes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum

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7 January 2021

Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Degradation of CFTR by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Escherichia coli preprotein translocase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Determination of the transmembrane topology of yeast Sec61p, an essential component of the endoplasmic reticulum translocation complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980222-1

7 January 2021

Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein

1 reference

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7 January 2021