A dimerization-dependent mechanism drives RAF catalytic activation (Q27865239)

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English	A dimerization-dependent mechanism drives RAF catalytic activation	scientific article

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scholarly article

1 reference

16 November 2016

A dimerization-dependent mechanism drives RAF catalytic activation. (English)

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16 November 2016

B-Raf proto-oncogene, serine/threonine kinase

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

author name string

Thanashan Rajakulendran

1

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Martin Lefrançois

3

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Marc Therrien

5

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Malha Sahmi

2

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Frank Sicheri

4

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language of work or name

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publication date

24 September 2009

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1 reference

461

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542-5

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7263

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Therapeutic strategies for inhibiting oncogenic BRAF signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the BRAF gene in human cancer

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase complement of the human genome

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of pseudokinases

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and selective pyrazole-based inhibitors of B-Raf kinase

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of somatic mutation in human cancer genomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KSR is a scaffold required for activation of the ERK/MAPK module

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conformational plasticity of protein kinases

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RAF proteins take centre stage

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https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coot: model-building tools for molecular graphics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SWISS-MODEL: An automated protein homology-modeling server

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active Ras induces heterodimerization of cRaf and BRaf

1 reference

https://pubmed.ncbi.nlm.nih.gov/19727074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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