Autophagy fights disease through cellular self-digestion (Q27860902)

Autophagy in the Pathogenesis of Disease

Europe PubMed Central

title

Autophagy fights disease through cellular self-digestion (English)

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3

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Beth Levine

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2

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Daniel J. Klionsky

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4

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Mizushima Noboru

object named as

Noboru Mizushima

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1

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language of work or name

English

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publication date

28 February 2008

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published in

Nature

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volume

451

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issue

7182

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page(s)

1069-75

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cites work

1 reference

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

20 March 2017

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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

20 March 2017

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Ambra1 regulates autophagy and development of the nervous system

20 March 2017

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

20 March 2017

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

20 March 2017

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Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

20 March 2017

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

20 March 2017

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

20 March 2017

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

20 March 2017

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

20 March 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

20 March 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

20 March 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

20 March 2017

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

20 March 2017

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The roles of intracellular protein-degradation pathways in neurodegeneration

20 March 2017

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Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans

20 March 2017

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

20 March 2017

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

20 March 2017

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

20 March 2017

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

20 March 2017

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

20 March 2017

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

20 March 2017

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The role of autophagy during the early neonatal starvation period

7 April 2017

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Role of autophagy in cancer

7 April 2017

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

7 April 2017

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Autophagy in cell death: an innocent convict?

7 April 2017

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

7 April 2017

1 reference

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Potential therapeutic applications of autophagy

7 April 2017

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

7 April 2017

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HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein

7 April 2017

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Unveiling the roles of autophagy in innate and adaptive immunity

29 September 2017

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Autophagy and human disease

29 September 2017

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Innate and adaptive immunity through autophagy

29 September 2017

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Eating the endoplasmic reticulum: quality control by autophagy

29 September 2017

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Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

29 September 2017

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy gene-dependent clearance of apoptotic cells during embryonic development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy and cell death.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Protein turnover via autophagy: implications for metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy delays apoptotic death in breast cancer cells following DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Signalling and autophagy regulation in health, aging and disease

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy and its possible roles in nervous system diseases, damage and repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy signaling and the cogwheels of cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy and aging: the importance of maintaining "clean" cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Chaperone-mediated autophagy in aging and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Autophagy in metazoans: cell survival in the land of plenty

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Targets for antiageing drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Eating oneself and uninvited guests: autophagy-related pathways in cellular defense

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

The molecular machinery of autophagy: unanswered questions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Cellular autophagy: surrender, avoidance and subversion by microorganisms

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Effect of thiol antioxidant on body fat and insulin reactivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

29 September 2017

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Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age.

27 November 2018

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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670399

27 November 2018

Identifiers

DOI

10.1038/NATURE06639

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Dimensions Publication ID

571700

1025718085

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571700

1 reference

1 reference

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