Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes (Q27853201)

Fabian V Filipp

15

0 references

Jean Yang

Jean Y Yang

10

0 references

Carleen Cullinane

Carleen Cullinane

6

0 references

Grant McArthur

Grant A McArthur

14

0 references

Graham J Mann

Graham J Mann

12

0 references

Jason Madore

Jason Madore

11

0 references

author name string

Jessamy C Tiffen

1

0 references

Dilini Gunatilake

2

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Kavitha Gowrishankar

4

0 references

Anja Heinemann

5

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Ken Dutton-Regester

7

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Gulietta M Pupo

8

0 references

Dario Strbenac

9

0 references

Nicholas K Hayward

13

0 references

Peter Hersey

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

16

0 references

language of work or name

English

0 references

publication date

29 September 2015

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published in

Oncotarget

0 references

volume

6

0 references

issue

29

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page(s)

27023-36

0 references

cites work

1 reference

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The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

29 September 2017

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Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

29 September 2017

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MDA-7/IL-24: multifunctional cancer killing cytokine

29 September 2017

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Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells

29 September 2017

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29 September 2017

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Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivo

29 September 2017

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Interplay between the cancer genome and epigenome

29 September 2017

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In vitro three-dimensional tumor microenvironment models for anticancer drug discovery.

29 September 2017

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Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.

29 September 2017

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29 September 2017

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Epigenetic regulation of skin: focus on the Polycomb complex

29 September 2017

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The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells

29 September 2017

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Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737.

29 September 2017

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Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

29 September 2017

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Gene expression profiling indicate role of ER stress in miR-23a~27a~24-2 cluster induced apoptosis in HEK293T cells

29 September 2017

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EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression

29 September 2017

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

29 September 2017

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29 September 2017

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29 September 2017

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Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

29 September 2017

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Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells

29 September 2017

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ATF3 transcription factor and its emerging roles in immunity and cancer

29 September 2017

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29 September 2017

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29 September 2017

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A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.

29 September 2017

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Expression of polycomb group protein EZH2 in nevi and melanoma

29 September 2017

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DNA methylation and gene silencing in cancer

29 September 2017

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Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma

29 September 2017

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29 September 2017

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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

29 September 2017

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27 November 2018

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modeling Melanoma In Vitro and In Vivo.

1 reference

PubMed

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